FAT SOLUBLE VITAMINS Dr Egendra K Shrestha - PowerPoint Presentation

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FAT SOLUBLE VITAMINS

Dr Egendra K Shrestha

M V Sc

Role of Vitamin A

Synthesis of glycoprotein to maintain integrity of epithelial cells.

In bone formation synthesis of mucopolysacharides. Synthesis of the visual pigment Rhodopsin. Retinol and retinoic acid (RA) are essential for embryonic development during fetal development.

Vitamin A-Retinol

Inadequate

retinol available to the retina results in impaired dark adaptation, known as "night blindness."

Mild vitamin A deficiency may result in changes in the conjunctiva (corner of the eye) called Bitot's spots. Severe or prolonged vitamin A deficiency causes a condition called xeropthalmia (dry eye) characterized by changes in the cells of the cornea that ultimately result in corneal opacity,

keratinization

of the cornea, corneal ulcers, scarring, and blindness.

Clinical signs

-Deficiency symptoms

Sometimes vitamin A deficiency can lead to obstruction of

lacrimal

ducts due to degenerated epithelial cells leading to decreased output of tears. Vitamin A is needed for bone formation. If vitamin A is deficient optic foramen is not formed properly. Small size optic foramen leads to the constriction of optic nerve. Permanent damage to the nerve can lead to permanent blindness.

Symptoms…

Infection of gastrointestinal tract, respiratory tract,

uro

genital tract and skin is common in Vitamin A deficiency. Deficiency of vitamin A can lead to infertility or sterility in male. Deficiency of vitamin A can lead to vaginitis, abnormal estrous cycle, early embryonic mortality, abortion and defective formation of

foetus

in females. Deficiency of vitamin A can lead to developmental bone deformities. Vitamin A deficiency leads to elevated

cerebro

spinal fluid (CSF) pressure results in thickened

duramater

leading to under absorption of CSF.

Clinical signs...

Calf: 1000000 to 1500000 IUCow (adult):250000

-2500000IU

Lamb :125000-250000 IUKid :125000-250000 IUSheep: 250000-500000IUPig :250000-500000IUHorse :200000-300000IU

Daily requirements

Excess- Clinical signs

Over consumption of preformed vitamin A is called

hypervitaminosis A. Symptoms include nausea, headache, fatigue, loss of appetite, dizziness, and dry skin. SupplementationOils from livers of certain fish (Cod and Halibut), Egg yolk and milk fat.

Role of Vitamin DVitamin D helps in absorpsion of Ca from the gut

Helps in proper growth of bone

Deficiency cause rickets in young animal and osteomalacia in older animalsVitamin D

Rickets

Calcium and Phosphorus deposition in bones is affected and the bones are weak, more prone to fractures and deformities.

The conditions commonly seen are bowing of legs, swollen knees and hock and arching of back. Occasionally there is paralysis. Rickety Rosary – enlargement of Osteochondral junction in ribs are also noticed.

Clinical signs- Deficiency

Resorption calcium and phosphorus from the bone that was already laid down.

Bones become weak, more prone to fractures and deformities.

It can occur in pregnant and lactating animals, which require increased amount of calcium and phosphorusDeficiency – Osteomalacia

Calf: 150000-225000 IU

Cow :adult37500-375100IU

Lamb :18750-37500 IUKid :18750-37500IUPig : 18750-37500IUHorse :6.6 IU/kgDog: 22-275 IU/kgRequirements

Toxicity – Clinical signs

Vitamin D toxicity (

hypervitaminosis D) induces abnormally high serum calcium levels (hypercalcemia), which could result in bone loss, kidney stones and Calcification of organs like the heart and kidneys if untreated over a long period of time. Supplementation

Cod liver oils (rich source),

Egg yolk and sun dried roughage/grains.

Vitamin E functions in the animal mainly as biological antioxidant.

In association with the selenium-containing enzyme glutathione

peroxidase, it protects cells against oxidative damage caused by free radicals. Vitamin E also plays an important role in the development and function of the immune system.Role of Vitamin E

The most frequent and the most important manifestation of

Vit E and

Selenium deficiency in farm animals is muscle degeneration (myopathy). Nutritional myopathy, also known as muscular dystrophy,

frequently occurs in cattle, particularly calves.

The myopathy primarily affects the skeletal muscles and the affected animals have weak leg muscles, a condition manifested by difficulty in standing and, after standing, a trembling and staggering gait.

Clinical signs –Deficiency

of Vit E

The animals are unable to rise and weakness of the neck muscles prevents them from raising their heads popularly known as

white muscle disease.

The heart muscle may also be affected and death may result.Encephalomalacia or Crazy chicks disease

Calf: 0.3-2mgLamb: 0.1-0.5 g

Pig: 0.5g

Dog: 30-100mgDaily Requirements

 Green fodders,

Cereal grains,

Vegetable oils, Fats, Nuts, Oil seeds and Legumes.Supplementation

of v

itamin E

Role

of Vitamin K

Vitamin K is required for synthesis of prothrombin in the liver, which is necessary for blood clotting. Deficiency – sweet clover disease Low Prothrombin level in blood leads to hemorrhagic conditions. In cattle sweet clover disease is associated with Vitamin K.

Sweet clover contains a compound

dicoumarol, which lowers prothrombin

content of blood

.

Delayed blood clotting

during hemorrhage Supplementation

Green leafy vegetables,

Synthesized by bacteria in gastro intestinal tract.

Vitamin K

Horse and cattle: 80-250mg

Dog and cat: 5-10 mg I/m

Requirements

THANKS