INDOLE ALKALODS a class of alkaloid containing a structural moiety of indole many indole alkaloids also include isoprene groups and are thus called terpene indole or ID: 929892
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Slide1
lec4
Pharmacognosy
alkaloids
Slide2INDOLE ALKALODS
a class of
alkaloid
containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine.
Slide3BIOSYNTHESIS
Slide4reserpine
Slide5physostigmine
,neostigmine,pridospermin
Slide6Semisynthetic
physostigmine
Slide7Ergot alkalods
Slide8Ergotamine
Is used to relief migraine and is still used today
It reduces vasodilatation , side effects include gangrene
Slide9The ergot alkaloid were used as a template for the semi-synthetic of
bromocriptine
,
pergolide and cabergolide, which have use in neurological disorder such as Parkinson’s disease.Ergot can cause hallucination and the hallucinogenic drug of abuse LSD(lysergic acid diethylamide) is structurally relatted to them.LSD
Slide10psilocybin
Mushrooms of the genera
Psilocybe
, Panaeolus, Conocybe and Stropharia are known to produce psychoactive substance such as psilocybin, which is salt in the fungi and is converted into psilocin in vivo.
Slide11Vinca rosa
Slide12Slide13Slide14Slide15Thank you for
listining