Stanley B DeVore MS Tammy Gonzalez PhD Michael G Sherenian MD Andrew B Herr PhD Gurjit K Khurana Hershey MD PhD Ann Allergy Asthma Immunol December 20201256628638 On the Surface ID: 930780
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Slide1
Slide2On the Surface
Skin Microbial Exposure Contributes to Allergic Disease
Stanley B. DeVore, MS
Tammy Gonzalez, PhD
Michael G. Sherenian, MDAndrew B. Herr, PhDGurjit K. Khurana Hershey, MD, PhD
Ann Allergy Asthma Immunol. December 2020;125(6):628-638
Slide3On the Surface
Key Messages
The commensal-epidermal homeostasis within healthy skin protects against allergic disease by inducing epidermal accumulation of commensal-specific type 1 and type 17 immune cells and increasing the expression of antimicrobial peptides and alarmins that target proallergic bacteria.
The composition of skin microbiome and epidermal barrier integrity are interdependent, and disruption in one (
eg, filaggrin mutations or dysbiosis) disrupts the other.Skin microbiome dysbiosis contributes to progression and exacerbation of allergic diseases, such as atopic dermatitis, food allergy, allergic rhinitis, and asthma.Current and potential treatments affecting the skin microbiome include emollients, restoration of skin commensals and antimicrobial peptides, and anti-TH2 biologic therapy.Maintenance of the skin barrier is the primary prevention for the development or exacerbation of atopic disorders; however, studying preventions targeting the skin microbiome is needed.
DeVore, et al. Ann Allergy Asthma Immunol. December 2020;125(6):628-638
Slide4Properties of the Epidermal Barrier
DeVore, et al. Ann Allergy Asthma Immunol. December 2020;125(6):628-638
Slide5Adaptive Immunity in
Commensal-Epidermal Homeostasis
DeVore, et al. Ann Allergy Asthma Immunol. December 2020;125(6):628-638
Slide6Effect of the Skin Microbiome on Allergic Disease
DeVore, et al. Ann Allergy Asthma Immunol. December 2020;125(6):628-638
Slide7Interventions Influencing the Skin Microbiome
DeVore, et al. Ann Allergy Asthma Immunol. December 2020;125(6):628-638
Slide8Exposomal
Research in the Context of Birth Cohorts
What Have They Taught Us?
Narges Baluch, MD
Mallory Gallant, MScAnne K. Ellis, MD, MSc, FRCPC
Ann Allergy Asthma Immunol. December 2020;125(6):639-645
Slide9Exposomal
Research in the Context of Birth Cohorts
Key Messages
Exposome complements the genome by encompassing all human environmental exposures from conception onward.
Exposome is composed of the following 3 overlapping domains of exposures: general external, specific external, and internal.Assessment of exposome in critical stages of life is important for understanding the link between environmental exposures and health outcomes.Birth cohorts provide an ideal study setting for exposomal research because environmental exposures can be assessed from prenatal period to years after birth.
Baluch, et al. Ann Allergy Asthma Immunol. December 2020;125(6):639-645
Slide10Exposome Domains Consist of General External, Specific External, and Internal Domains
Baluch, et al. Ann Allergy Asthma Immunol. December 2020;125(6):639-645
Slide11The Hypothesis of “Developmental Origins of Health and Disease” Highlighting the Impact of Genetic and Environmental Factors
Baluch, et al. Ann Allergy Asthma Immunol. December 2020;125(6):639-645