Step 1: What are your lab processes and what are the high level hazards - PowerPoint Presentation

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Step 1: What are your lab processes and what are the high level hazardsPlease note if your research involves:Biohazards, a Biological Use Authorization is required (see Step 5)Radioactive Materials or Raidation emtting devices, the apporiate paperwork must be submitted to NCSU radiation Safety. This is not a local service

Step 2: Compile a chemical inventory for your lab using NCRC template

Step 3: Request Lab Safety Plan Number: https://www3.acs.ncsu.edu/sp/ehs-sp/Request.php

Step 4A: General Area and Contact Information (cover sheet)

List of ProcessesProcess HazardControls

Step 4: Begin Lab Safety Plan:

http://safety.ncsu.edu/etehs/BasicFunctions/ListPlans.aspx

Lab Safety Plan Process

Step 4B: Safety information and exposure control by Process (hint: The quickest way to complete this section is to create a word document with each of the following headings and then cut and paste into Lab Safety PlanStep 4B1: Hazardous Chemicals/Chemicals Classes List each chemical used in the process and it Hazard ClassStep 4B2: Potential Hazards

of each chemical. Describe all potential hazards for each process (physical, biological or chemical).  If the laboratory contains numerous chemicals, it is acceptable to define the hazard for a class of chemical such as corrosive, oxidizer, flammable, etc.  Permissible Exposure Limits (PEL) and exposure signs/symptoms must be detailed if not available on the Material Safety Data Sheet (MSDS).

Step 4B3: Engineering and Ventilation Controls – : Describe all engineering controls used to reduce employee exposures to hazardous chemicals or physical agents, such as ventilation devices, aerosol suppression devices, shielding and safety features on equipment.

Additional information on ventilation controls

Step 4B4: Special Handling and Storage Requirements List all storage requirements (i.e. segregation, flammable storage cabinets, etc) for hazardous materials in the area.  Include specific storage locations, special containment devices, restricted access plans, designated area and additional information on the proper storage and handling of hazardous materials; Additional guidance on storageLab Safety Plan Process

Step 4B: Safety information and exposure control by Process (continued)Step 4B6 : Spill and Accident Procedures: : Indicate how spills or accidental releases will be handled and by whom.  Additional guidance on emergencies is available from Dan Hurley

Step 4B6: Special Animal Use Precautions: All animal research on the NCRC is conducted in the DHMRI Center for Laboratory Animal Science. Form required for the

the use of chemical or biological agents in animal include:IACUC Protocol Appendix 3: Test Substances DHMRI HAZARDOUS MATERIAL USE IN ANIMALS FORM

IACUC Protocol Appendix 6: Special Husbandry and Procedures If the material is biological agent or toxin:DHMRI Biosafety Protocol DHMRI

DHMRI Laboratory Checklist – Biological Safety Level 2Step 4B8: OtherStep 4B7: Decontamination Procedures: Are there any special decontamination procedures necessary for the any of the materials in this Process. Decontamination procedures for biological agents and toxins, and/or radioactive materials must be cobver in the appropriate institutional form

Lab Safety Plan Process

Step 4D: Add the following attachments Evacuation Plan Chemical InventoryFirst FloorSecond FloorThird

FloorFourth Floor

Step 4C: Personal Protective Equipment

Step 4E:

Target

Chemicals

Step 4F:

Target

Processes

Step 4G:

Security

Checklist

Lab Safety Plan Process

Step 4H1: SUPERVISOR'S SELF-ASSESSMENT CHECKLIST CERTIFICATIONI am the responsible principal investigator/supervisor for this area(s)and have completed the annual self-audit checklist Click here for self assessment Step 4H: FINAL SIGNATUREStep 4H2:

REQUIRED WASTE MINIMIZATION CERTIFICATION I have made a good faith effort to minimize my waste generation and select the best waste management method that is available to me.

Step 4H3: LABORATORY CHEMICAL INVENTORY DECLARATIONI am the responsible principal investigator/supervisor/manager for this facility and attest the chemical inventory provided is a good faith effort for accuracy and completeness at the time of submission.

Lab Safety Plan Process

Step 4H: FINAL SIGNATUREStep 4H4: DEPARTMENT OF HOMELAND SECURITY CHEMICAL INVENTORY DECLARATIONI certify under penalty of law that the following chemicals are under my control in the building and room or labs assignedORI certify under penalty of law that I do not possess in my labs or any space assigned to me any of the chemicals listed on the DHS Chemical list provide

Step 4H2: EMERGENCY FACILITIES CLOSURE CHECKLISTI have completed the Emergency Facilities Closure Checklist and have posted our closure plan with my Safety Plan. Click here for closure checklist

Lab Safety Plan Process

Step 5: Apply for Biological Use applicationStep 5A: Review Laboratory Biosafety Manual to determine requirementsStep 5B: Complete Laboratory Checklist for Biological

Safety Level 2 (BSL-2) at NC State University. Dan Hurley will help you conduct your self-inspection and provide information on how to achieve compliance

Step 5C: Complete Biological Use Authorization (BUA).

Step 5C: If project involves Human blood, cells etc., a Model Exposure Control Plan will be required.

Lab Safety Plan ProcessStep 5C1: If project involves Human blood, cells collected by NC State faculty and staff, NCSU IRB review and approval is required.Step 5C2: If project involves Human blood, cells collected by entity, ensure that that entities IRB has reviewed the project.

Step 5: Apply for Biological Use Authorization Step 6: Request Door Sign from Dan Hurley using attached form

Step 5D: Animal materials

Lab Safety Plan Process

Step 5D1: Animal materials acquired from other entities – Ensure providing entities IACUC has approved the transfer of material

Step 5D1: Animal materials acquired from DHMRI Center laboratory Animal Science – Ensure DHMRI IACUC has approved the transfer of materialStep 5E: Biological materials used in anImals – DHMRI CLASStep 5E1: Complete DHMRI IACUC and DHMRI Institutional Biosafety Committee requirement found on the NCRC Members Portal. Note: NCSU IBC approval of the laboratory portion of your research program will required before the DHMRI IBC will consider your project. After Biosafety Approvals have been obtained, the DHMRI IACUC will review your project.