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Credibility in multiscale modeling of bone environment response to metastatic cancer Credibility in multiscale modeling of bone environment response to metastatic cancer

Credibility in multiscale modeling of bone environment response to metastatic cancer - PowerPoint Presentation

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Uploaded On 2022-07-28

Credibility in multiscale modeling of bone environment response to metastatic cancer - PPT Presentation

David Basanta and Conor Lynch The problem A Osteoclastogenesis Monocyte Macrophages Osteoclast Osteolysis Osteogenesis MMP BMP MMP MMP BMP Osteoblast MSC and OB Precursors Inflammatory Macrophages ID: 930406

macrophages inflammatory credibility mmp inflammatory macrophages mmp credibility monocyte bone polarization bmp anti

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Presentation Transcript

Slide1

Credibility in multiscale modeling of bone environment response to metastatic cancer

David Basanta and Conor Lynch

Slide2

The problem

A

Osteoclastogenesis

Monocyte Macrophages

Osteoclast

Osteolysis

Osteogenesis

MMP

BMP

MMP

MMP

BMP

Osteoblast

MSC and OB Precursors

Inflammatory Macrophages

Anti-Inflammatory Macrophages

Injury

Differentiation

Maturation

Pro-inflammatory

Polarization

Anti-inflammatory

Polarization

Monocyte Recruitment

Bone Macrophages

Slide3

3 levels of credibility