Etab A AL Mosawe Cell death Cell death falls into two main categories Apoptosis and necrotic cell death Types of Cellular Necrosis Liquefaction necrosis Digestive enzymes released by necrotic cells soften and liquefy dead tissue Occurs in tissues such as the brain that are r ID: 930519
Download Presentation The PPT/PDF document "Cell death 3 rd stage MSc" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Cell death
3
rd
stage
MSc
Etab
A. AL-
Mosawe
Slide2Cell death
Cell
death falls into two main categories:
Apoptosis
and
necrotic cell death
Types of Cellular Necrosis
Liquefaction necrosis Digestive enzymes released by necrotic cells soften and liquefy dead tissue. Occurs in tissues, such as the brain, that are rich in hydrolytic enzymes.
Caseous
necrosis Dead tissue takes on a crumbly, “
cheeselike
” appearance. Dead cells disintegrate but their debris is not fully digested by hydrolytic enzymes. Occurs in conditions like tuberculosis where there is prolonged inflammation and immune activity.
Coagulative necrosis Dead tissues appear firm, gray and slightly swollen. Often occurs when cell death results from ischemia and hypoxia. The acidosis that accompanies ischemia denatures cellular proteins and hydrolytic enzymes. Seen with myocardial infarction, for example.
Slide3Types of tissue repairRepair by regeneration
Repair by connective tissue replacement
Slide425-Kidney with coagulative necrosis: Tissue structure and cell out line are preserved. Nuclei are pyknotic
but are still visible.
Slide526-Lung with caseous necrosis: At the upper right is amorphous pink
caseous
material composed of the necrotic elements of the granuloma as well as the infectious organisms. This area is ringed by the inflammatory component with epithelioid cells, lymphocytes, and fibroblasts.
Slide627- Lung with liquefactive necrosis: Seen here are two lung abscesses, one in the upper lobe and one in the lower lobe of this left lung. An abscess is a complication of severe pneumonia, most typically from virulent organisms such as S. aureus. Abscesses are complications of aspiration, where they appear more frequently in the right posterior lung.
Slide7This is a cerebral abscess. There is a liquefactive center with yellow pus surrounded by a thin wall. Abscesses usually result from hematogenous spread of bacterial infection, but may also occur from direct penetrating trauma or extension from adjacent infection in sinuses.
Slide8This trichrome stain demonstrates the light blue connective tissue in the wall of an organizing cerebral abscess. Normal brain is at the right and the center of the abscess at the left.
Slide9Slide10Adipost tissue with fat necrosis: F.A. binds with Metallic ions especially Na, K, Ca. soap is formed within adipocytes. adipocytes are replaced by opaque, homogenous
substance.Stains
pink with K
soap.Nuclei
are
pyknotic
.
Slide11Zenkers Necrosis: coagulation of the protein of the sarcoplasm of striated muscle