oligodendrocytes in the active areas of a chronic active MS lesion Staining for IFNa b e h k in green and in a for B cells CD19 in d T cells CD3 and in g astrocytes GFAP and in j ID: 931722
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Slide1
Figure e-1 A: IFN-a is not expressed in CD19+ cells, CD3+ cells, astrocytes or
oligodendrocytes
in the active areas of a chronic active MS lesion.
Staining for IFN-a (b, e, h, k, in green) and in a for B cells (CD19), in d: T cells (CD3) and in g: astrocytes (GFAP) and in j:
oligodendrocytes
(PLP ). c, f,
i
, l (case 5) show absence of co-localization of IFN-a and MHC c
1
1
lass II in B cells, T cells, astrocytes and
oligodendrocytes
(yellow). Scale bar: 10 µm.
Slide2Figure
e-1B
:
Plasmacytoid
dendritic cells are not present in MS lesions.
a-c
:
Immunohistochemical
staining of formalin-fixed sections from MS
autoptic
specimens using
plasmacytoid
dendritic cell (
pDC
) markers as indicated.
d-f
:
Immunohistochemical
staining of formalin-fixed sections from a reactive lymph node using
pDC
markers as indicated. Note that CD123 also stains high endothelial
venules
. Scale bar: 200 µm.
g
:
Immunohistochemical
staining of BDCA2 in formalin-fixed normal brain. Scale bar: 100 µm.