Antibody Conjugation Services - PDF document

Antibody Conjugation Services BOC Sciences provides personalized antibody conjugation services to support research and development in the field of antibody drugs. As a leading service provider of bioconjugation, our best antibody bioconjugation services include antibody conjugated PEG, biotin, fluorescence dye, enzyme and oligonucleotide, which have been proven to improve the function and performance of antibody drugs, as well as to use for imaging and detection. Furthermore, antibody - drug conjugation services are provided to support the forefront of antibody - drug conjugates (ADCs) development. Introduction Antibody - based drugs have become an important class of biological drugs. The monoclonal antibody (mAb) and its derivatives, such as antibody - drug conjugates (ADCs), bispecific antibodies, have been widely used in the effective treatment of human diseases, particularly in the fields of immunology and oncology. In antibody - based therapy, various antibody derivatization approaches are used to improve the performance of antibodies or to test antibody drugs. For instance, the conjugation of PEG to antibodies can enhance the so lubility of antibodies, reduce immunogenicity, and increase the circulating half - lives of antibodies. In addition, exploiting the character of antibodies binding specifically to antigens, antibodies labeled with chromogenic agents, such as fluorophore, enz yme, biotin, etc. , provides a tool for the localization, characterization and quantification of antigens in biological tissues. With increased understanding of immunobiology and the continued development of molecular biology methods, it is believed that th e possibilities of antibody - based therapeutics are bounded only by the scope of human ingenuity. Application Antibody conjugates have been widely used in antigen detection and disease diagnoses, such as proteins identification and cancerous tumors diagnosi s, involving chromogenic immunohistochemistry (CIH) and immunofluorescence technologies. Improvements in the methods for antibody conjugate synthesis promote the development of antibody - drug conjugates (ADCs), which sensitively distinguish healthy tissues from diseased tissues for targeting cancer while minimizing healthy tissue exposure. As a new class of biomolecules, antibody - oligonucleotide conjugates (AOCs) have become important biotechnology for imaging, detection, and therapeutics such as targeted si RNA and antisense delivery. Our Advantages  Profound knowledge and extensive experience in antibody conjugation  Comprehensive antibody conjugation service and leading antibody technology  People and suites that specialize in ADC development, manufacturing an d testing  High levels of antibody recovery so to save your precious reagents  Full technical support  Reliable and reproducible result  Detailed report and data analysis, including results and discussion Project Workflow Related Links PEG Conjugated Antibodies PEG conjugated antibodies offer reduced immunogenicity, enhanced solubility, stability and improved bioavailability compared to prototype an tibodies while retaining the maximum biological activity. Biotin Labeled Antibody Biotin - labeled antibodies are endowed with strong affinity for streptavidin and avidin, which can be used in histocytochemistry, immunoassays, and fluorescence - based flow cytometry. Fluorescence Labeling of Antibody Fluorophore - labeled an tibodies retain antibodies activity and exert additional fluorescent tracer effects. Fluorescent dyes, including FITC, rhodamine, cy3, cy5, etc. , can be used to label antibodies. Enzyme Labeling of Antibodies Antibody labeling antibodies is mainly used for antigen localization analysis. Various reporting enzymes, such as horseradish peroxidase (HRP) and many other enzymes, can bind to antibodies. Antibody Oligonucleotide Conjugation Antibody - oligonucleotide conjugates (AOCs) have been widely used in many diagnosis and treatment applications, such as biomarker discove ry, clinical diagnosis, and protein - protein interactions. Antibody - Drug Conjugation Antibody - drug conjugates (ADCs) combine the monoclonal antibodies targeting capability and cancer - killing of cytotoxic drugs, can target cancer while minimizing exposure to healthy tissue.