IMI Scientific Symposium Brussels Belgium Quantitative PET Imaging from Research to Clinical Use Amyloid Imaging to prevent Alzheimers Disease AMYPAD Diagnostic study ID: 1011546
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1. Fiona Heeman22 & 23 October 2018 • IMI Scientific Symposium • Brussels, BelgiumQuantitative PET Imaging; from Research to Clinical Use
2. Amyloid Imaging to prevent Alzheimer’s Disease AMYPAD Diagnostic studyPrognostic study8 centersUp to 20 centers1200 scans3000 scansAssess diagnostic value AβRisk stratificationUsefulness Aβ imaging in patient managementSecondary prevention studies Patient APatient BPatient APatient BMethodology
3. PET allows for visualization& quantification of amyloid-β in the brainRationale 0 min90min0 min110 min110 minDiagnostic usePositive/negative amyloid scanIndirect measure of amyloid loadLongitudinal measurements-Treatment response/ disease progression- Direct measure of amyloid loadStaticDynamicCoffee-break protocol90 minx min
4. Data & Methods Clinical data: AD & control subjects for both amyloid PET tracersTracer kinetics simulated based upon clinical dataAssessment of the bias in amyloid load quantificationSimulated data covered the whole disease spectrumRepresented various noise levelsDifferent scanning protocols were deleted
5. Optimal coffee-break scanning protocol: 0-30 minutes & 90-110 minutesConclusion0 min110 min90 min30 min45 min75 minPatient comfort: 60 min restInterleaved scanningEfficient tracer batch& scanner time useAccurate estimates of amyloid loadDirect comparison with static scans60 min