Descriptive Features and Incidence Trends in California Cyllene Morris DVM PhD California Cancer Registry Based on morphologic features epithelial ovarian tumors classified as Benign Borderline or Low Malignant Potential ID: 1041337
Download Presentation The PPT/PDF document "Borderline Ovarian Cancer:" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
1. Borderline Ovarian Cancer:Descriptive Features and Incidence Trends in CaliforniaCyllene Morris, DVM, PhDCalifornia Cancer Registry
2. Based on morphologic features, epithelial ovarian tumors classified as:BenignBorderline or Low Malignant Potential (LMP)MalignantStill unresolved: are LMP precursors of invasive ovarian cancer (OC) or separate entities?Few serous LMP tumors progress to malignant OC, but some mucinous LMP tumors do.Background
3. LMP tumors no longer reportableHoweverLMP tumors included in large screening trials in the US and UKLMP Tumors Still Collected in California
4. Both staged I – IV (AJCC and FIGO), based on tumor extension (nodes and tumor size do not affect stage)LMP: node Involvement predicts recurrence, but not survivalSurvival: distant stage LMP ≅ localized OC (excellent prognosis)LMP X Malignant Tumors
5. Similar epidemiologic features for LMP and invasive OC, except:LMP: more likely among younger womenBRCA1 – BCRA2 mutations in 24.2% of invasive OC and 4.3% of LMP tumors (2005 Israeli study) Oral Contraceptives: no protective effect for LMP?Previous Studies
6. Describe epidemiologic features of LMP tumors compared with invasive OC in CaliforniaEvaluate incidence trends of LMP tumors by race/ethnicity in the diverse California populationObjectives
7. 9,433 cases of LMP ovarian tumors diagnosed 1988-2009 (as of 03/31/10)Microscopically confirmedCases detected through autopsy or death certificate only excludedIncidence trends: JoinPoint (1988-2007)Methods
8. LMPInvasiveRace/Ethnicity & AgeN%N%NH White5,85562.133,66670.7African American4234.52,1714.6Hispanic2,23023.67,32115.4NH Asian/PI8088.64,1278.7Other/Unknown Race1171.23320.7Median Age at DX4663Invasive and LMP Ovarian Tumors: DemographicsNH: Non-HispanicPI: Pacific Islander
9. Age-Specific Rates: Invasive and LMP Tumors, California, 1988-2007
10. Age-Specific Rates: LMP Tumors
11. Incidence Rates of Invasive and LMP Tumors: California, 1988 -2007
12. JoinPoint Trends in the Incidence of LMP Tumors: California, 1988-2007
13. Joinpoint trends in LMP tumors by Race/Ethnicity: California, 1988-2007
14. Joinpoint trends in LMP tumors:Hispanic and African American Women
15. AJCC Stage at Diagnosis of LMP and Invasive Tumors: California, 2000-2008
16. LMP: 12.2 cm (4.8 inches)Invasive: 10.6 cm (4.2 inches)P-value < 0.001Tumor SizeLMP: slightly larger than invasive tumors
17. Invasive and LMP Tumors Laterality: California, 1988-200
18. Relative 5-Year Survival for Invasive (by Stage) and LMP Tumors: California, 1988 -2008
19. Relative 5-Year Survival for LMP Tumors, by Race/Ethnicity: California, 1988 -2008
20. Substantial differences between Invasive and LMP tumors:Age-specific ratesRace/Ethnicity: Hispanics 24% casesUnlike invasive OC, incidence of LMP tumors among African American and Hispanic womenEven though majority of LMP tumors are Stage I, relative survival not 100%, and is lower among African AmericansConclusions