Khe Sahn Fighting off the Viet Cong Theyre still there hes all gone Bruce Springsteen Born in the USA Sony Records 1984 2 Introduction 2 of 2 The Vietnam Era Twin VET Registry ID: 1047805
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1. 1Introduction 1 of 2Had a brother at Khe SahnFighting off the Viet CongThey're still there, he's all goneBruce Springsteen Born in the U.S.A Sony Records, 1984
2. 2Introduction 2 of 2The Vietnam Era Twin (VET) Registry: A 30 Year Compendium of Scientific ResearchJack Goldberg, PhDSenior Epidemiologist, VET Registry, Seattle Epidemiologic Research and Information Center, VA Cooperative Studies ProgramEmeritus Research Professor of Epidemiology, University of Washington
3. 3The VET RegistryA Unique Scientific Resource Many large twin registries in the Nordic countries Hundreds of studies of chronic disease and psychiatric conditionsNo other national twin registry in the United States
4. 4Presentation Outline History and Development of the VET RegistryWith a few digressionsVET Registry scientific productivityPublicationsHow many?Quality Number of citations Journal Citation Report
5. 5The VET Registry: DevelopmentConcern about the health effects of Agent Orange
6. 6Map of Aerial Herbicide Spray Missions in southern Vietnam
7. 7Political cartoon 1 of 3
8. 8Political cartoon 2 of 3
9. 9political cartoon 3 of 3
10. 10The VET Registry: Development1 of 7Research projects into the health of Vietnam veterans by the DoD, VA and CDC1981 a VA RFP for studies on Agent OrangeSeth Eisen and William True at the St. Louis VA proposed a co-twin control study
11. 11The VET Registry: Development2 of 7Proposed study Compare health outcomes in 500 male-male monozygotic veteran twin pairs discordant for service in VietnamOne brother in Vietnam and a co-twin in the military but did not serve in VietnamAfter much review the VA decides to provide funding for protocol development
12. 12The VET Registry: Development3 of 7VA Twin StudyVA Cooperative Studies ProgramAssigned to Hines VAManaged by William Henderson, Director of the Hines CSPCC The project is split Agent Orange clinical examRegistry component
13. 13From Science 1984
14. 14News clipping
15. 15The VET Registry: Development4 of 7Identifying potential veteran twins by record linkage:Same last name, different first nameSame date of birth (1939-1957)Military service between 1965-1975Exact match on first 5 digits of the Social Security Number
16. 16The VET Registry: Development5 of 7~15,000 potential twin pairs are identifiedRetrieve hard copy military records at National Personnel Record CenterConfirm twinship Abstract military record data
17. Images of records storageNational Personnel Records Center17
18. 18Seven Shelf-Miles of Vietnam-Era Records Scene from “Raiders of the Lost Ark” (1981)
19. 19The VET Registry: Development6 of 7~7,500 twin pairs identified!!!!!Military record info Branch of serviceDate of enlistment and discharge Place of serviceHeight and weightMeasure of general intelligenceCombat-related medals
20. 20The VET Registry: Development7 of 7Descriptive StatisticsMedian year of birth = 194992% white Vietnam service21% both served in Vietnam36% discordant for Vietnam 43% neither served in Vietnam
21. 21The VET Registry: Some HistoryTime at Hines VA CSPCCEarly Hines years (1983-1990)CSP # 256 (Vietnam Era Twin Study) is completedRegistry evolves under Bill Henderson Later Hines years (1991-2000)Strong VA support Creation of an external scientific oversight groupDevelop rules for accessing the RegistryActive research portfolio by investigatorsMail and telephone surveysFirst in-person examinations (1996)Offspring of twins added to Registry (1998)
22. 22The VET Registry: More HistoryTime at Seattle VA CSPEC (2001-2018) Registry is transferred within CSP to Seattle VA CSPECJack Goldberg transfers with the RegistryRegistry Director is Ed Boyko and then Nick SmithMail and telephone studies continueIn-person studies accelerateCreation of the Registry biorepository (2002)
23. 23Digression: Memories of the Early Days(1983)Epidemiologist job description at Hines for twin study
24. 24Digression: Memories of the Early Days1 of 4(1989) Seth Eisen in Rome for the International Congress on Twin Studies meeting. He is digging through the hotel waste basket for his misplaced presentation slides.
25. 25Digression: Memories of the Early Days2 of 4(1988) Spark for the NHLBI study
26. 26Digression: Memories of the Early Days(1992)Harvard Drug Study team –William True, Michael Lyons, Seth Eisen, Nong Lin, Jack Goldberg
27. 27Digression: Memories of the Early Days3 of 4(1996) Alcohol Vulnerability Study Kick-off Meeting, Boston, MABack Row: Tom Doyle, Jack Goldberg, William Kremen, William True, Nong Lin, Seth Eisen, Mike NealeFront row: Rosemary Toomey, Michael Lyons, Krupa
28. 28Digression: Memories of the Early Days5 of 4(2002) Vietnam-Era Twin Study of Aging team -Seth Eisen, Jack Goldberg, William True, Michael Lyons, Hong Xian
29. 29Vietnam-Era Twin (VET) Registry MissionTo promote and advance high-quality scientific research in partnership with Vietnam-era Veteran twins and their familiesTo maintain a secure and current Registry database and biospecimen repository as a resource for future studiesTo treat Registry members and their families with respect and maintain their confidentiality
30. 30Methods for Assessing VET Registry Productivity1 of 2Search PubMed and Google Scholar for all peer-reviewed VET Registry papersCreate bibliographic database Categorize each paper Study team: Harvard Drug, Vietnam-Era Twin Study of Aging, Twin Heart, Pitman/Gilbertson/Shin PTSD, Jacob/Buchloz Offspring and Substance UseTwin or offspringData collection: self-report, in-person, biological, imagingTopic: mental health, PTSD, physical health, substance use
31. 31Methods for Assessing VET Registry Productivity2 of 2Measures of impactTotal number of citations to a VET Registry paper according to Google Scholar as of May 2018H-index: based on the set of most cited papers and the number of citations that they have been cited in other publications. The index can be applied to the productivity of a group of scientists.Journal Citation Report (JCR)A measure reflecting the yearly average number of citations to recent articles published in that journal (equal to the number of current year citations to all papers published in that journal during the previous two years).Examples of 2016 JCR: NEJM = 72.4, JAMA = 44.4, JAMA Psychiatry = 15.3, American Journal of Epidemiology = 4.8, Twin Research = 1.3
32. 32VET Registry ProductivityNumber of VET Registry papers: 30452 papers with a focus on PTSDTotal number of citations to VET Registry papers: 23,195H-index for VET Registry papers: 81Mean and Median JCR for VET Registry papers: mean = 5.3, median = 3.4
33. 33Graph 1 of 6Cumulative Number of VET Registry Papers
34. 34Graph 2 of 6Cumulative Number of VET Registry Papers by Study Team
35. 35Graph 3 of 6Cumulative Number of VET Registry Papers by Twin vs Offspring
36. 36Graph 4 of 6Cumulative Number of VET Registry Papers by Data Collection Method
37. 37Graph 5 of 6Cumulative Number of VET Registry Papers by Topic
38. 38Graph 6 of 6Cumulative Number of VET Registry Citations
39. 39Top Ten Most Cited Papers: VET Registry TITLECITED BYYEARSmaller hippocampal volume predicts pathologic vulnerability to psychological traumaMW Gilbertson, ME Shenton, A Ciszewski, K Kasai, NB Lasko, SP Orr, …Nature neuroscience 5 (11), 124214702002A twin study of genetic and environmental contributions to liability for posttraumatic stress symptomsWR True, J Rice, SA Eisen, AC Heath, J Goldberg, MJ Lyons, J NowakArchives of general psychiatry 50 (4), 257-2647681993Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilitiesMT Tsuang, MJ Lyons, JM Meyer, T Doyle, SA Eisen, J Goldberg, W True, …Archives of general psychiatry 55 (11), 967-9726701998Distinct genetic influences on cortical surface area and cortical thicknessMS Panizzon, C Fennema-Notestine, LT Eyler, TL Jernigan, …Cerebral cortex 19 (11), 2728-2735 6102009Common genetic vulnerability for nicotine and alcohol dependence in menWR True, H Xian, JF Scherrer, PAF Madden, KK Bucholz, AC Health, …Archives of general psychiatry 56 (7), 655-6615351999Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairsMT Tsuang, MJ Lyons, SA Eisen, J Goldberg, W True, N Lin, JM Meyer, …American journal of medical genetics 67 (5), 473-4774981996Common genetic vulnerability for pathological gambling and alcohol dependence in menWS Slutske, S Eisen, WR True, MJ Lyons, J Goldberg, M TsuangArchives of general psychiatry 57 (17, 666-6734132000Differential heritability of adult and juvenile antisocial traitsMJ Lyons, WR True, SA Eisen, J Goldberg, JM Meyer, SV Faraone, …Archives of general psychiatry 52 (11), 906-9153791995Sexual orientation and suicidality: a co-twin control study in adult menR Herrell, J Goldberg, WR True, V Ramakrishnan, M Lyons, S Eisen, …Archives of general psychiatry 56 (10), 867-8743361999Genetic and environmental contributions to smokingWR True, AC Heath, JF Scherrer, B Waterman, J Goldberg, N Lin, …Addiction 92 (10), 1277-12873061997
40. 40Top Ten Most Highly Rated Journals for VET Registry PapersJournal TitleJournal Citation Reports (JCR)Number of PapersJAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION44.41SCIENCE37.21JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY19.92CIRCULATION19.31NATURE NEUROSCIENCE17.81JAMA Internal Medicine16.53JAMA Psychiatry15.319AMERICAN JOURNAL OF PSYCHIATRY14.22NEURON14.01MOLECULAR PSYCHIATRY13.21
41. 41Top Fifteen Authors of VET Registry Papers AuthorTotal # of PapersLyons, MJ159Goldberg, J121Eisen, SA109Tsuang, MT101Xian, H91Kremen, WS90Franz, CE78True, WR75Panizzon, MS68Scherrer, JF62Jacobson, KC46Vaccarino, V45Bucholz, KK43Grant, MD40Jacob, T36
42. 42Table 1 of 1Mean and Median Number of Citations by Study CharacteristicsStudy characteristicsNMeanMedianStudy Type Twin2727940Mother/Offspring244929Data TypeSelf-reported2328644In-person1425724Biological1076424Imaging578029OutcomesMental health1838241PTSD6210861Physical health1034430Substance use908843Study GroupHarvard Drug7413778VETSA843719Twin Heart Study405039Pitman/Gilbertson/Shin1518079Jacob/Buchloz324329
43. 43Table 2 of 2Mean and Median Journal Citation Report by Study CharacteristicsStudy characteristicsNMeanMedianStudy Type Twin2725.53.7Mother/Offspring243.62.9Data TypeSelf-reported2325.33.3In-person1425.84.2Biological1076.34.5Imaging577.35.5OutcomesMental health1835.63.4PTSD626.33.3Physical health1035.94.2Substance use904.32.9Study GroupHarvard Drug745.43.2VETSA844.83.4Twin Heart Study406.44.5Pitman/Gilbertson/Shin158.05.4Jacob/Buchloz323.32.6
44. 44Productivity SummaryThe VET Registry is an amazing scientific resourceA large number of papers in high quality scientific journalsVET Registry papers are widely citedFundamental discoveries about PTSD, substance use disorders, aging, cognition and heart disease
45. 45The FutureThe best is yet to comeThe Registry is thrivingTwins are agingData repository is superbly curatedBiorepository with nearly 2000 samples and growingWhole Genome Sequencing on 1749 individuals
46. 46Specific thanks-today’s talk: Chris Forsberg, MS, BiostatisticanErin Acosta, MPH, Research AssistantShauna Biggs, MPH, Research CoordinatorCSP Seattle Epidemiologic Research and Information Center (ERIC)VA Puget Sound Health Care System
47. 47And a Grand Thanks to: 1 of 4THE VET REGISTRY TWINS!!!!!!!!
48. 48And a Grand Thanks to: 2 of 4 VA COOPERATIVE STUDIES PROGRAM
49. 49And a Grand Thanks to: 3 of 4VET REGISTRY DIRECTORS:William G. Henderson, PhD; Edward J. Boyko, MD, MPH; Nicholas L. Smith, PhD
50. 50And a Grand Thanks to: 4 of 4All OF THE VET REGISTRY STAFF 1983-2018Bill Henderson, Ed Boyko, Nick Smith