Drug Enforcement Administration - PDF document

1 Drug Enforcement Administration Divers
Drug Enforcement Administration Diversion ControlDivisionDrug & Chemical Evaluation Section KavaOtherNames: Ava, Intoxicating Pepper, Kawa Kawa, Kew, Sakau, Tonga, Yangona)September Introduction Kava, also known as Piper methysticum(intoxicating pepper), is a perennial shrub native to the South Pacific Islands, including Hawaii. is harvested for its rootstock, which contains the pharmacologically active compounds kavalactonesThe term kava also refers to the nonfermentedpsychoactive beverage prepared from the rootstock. For many centuries, Licit Uses: In the U.S., kavais sold as dietary supplements promoted as natural alternativeto antianxiety drugs and sleeping pills. Aanalysis of six kava clinical trials found that kava (60mg of kavalactones/day) produced a significant reduction in anxiety compared to placeboAnother metaanalysis found kava to be more effective thanplacebo in 3 out of 7 trials Chemistry and Pharmacology: The pharmacologically active kavalactonesare cit Uses: Information on the illicit use of kavain the U.S.is anecdotalBased on information on the Internet, kava is being used recreationally to relax the body and achieve a mild euphoria. is typically User Population Information on user populationin the U.S.is very limited. In the 1980s, kava was introduced to Australian Aboriginal communities where it quickly became a drug of abuse. It has become a serious social problem in regions of Northern Australia. Illicit istribution Kavais widely available on the Internet. Some websites promoting selling kava products also sell other uncontrolled psychoactive products such as Salvia divinorumeveral kava bars and lounges in the U.S.sell kava drinks.The National Forensic Laboratory Information System (NFLIS) and the System to Retrieve Information from Drug Evidence (STRIDE) Control Status: ava is not a controlled substance in the U.S.Due to concerns of ver toxicity, many countries including AustraliaCanada, France, Germany, Japan, Malaysia, Norway, Poland, Singapore, South Africa, Sweden, Switzerland, and the United Kingdom have placed regulatory controls on kava. Comments and additional information are welcomed by the Drug and Chemical Evaluation Section;Fax 571362Telephone 571362 3249, or Email DPE@usdoj.gov .