These example images are from a melanoma left and breast cancer right patient A potential therapeutic target for brain metastasis CIRP Our Discovery Brain metastases often have cancer cells ID: 1000124
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1. Problem: Why do brain metastases grow back after surgery?These example images are from a melanoma (left) and breast cancer (right) patient.A potential therapeutic target for brain metastasis: CIRPOur Discovery: Brain metastases often have cancer cells invading far into the brain. These invading cells are missed by the surgeon and are the cause of re-growth after surgeryWhen CIRP is deleted, cancer cells cannot efficiently grow in the brain Our Goal:Stratify clinical trials for patients with brain metastases based on non-invasive vs. invasive growth.Develop CIRP as a therapeutic target to treat brain metastases.Non-Invasive (42 patients)Invasive (63 patients)P = 0.003 (Statistically meaningful difference)1007550250Local Recurrence-Free Survival (%)0123Years Post-Surgery (Human Patients)None of the non-invasive brain metastases grew backAlmost half of the invasive brain metastases grew backInvasive brain metastases grow back after surgery while non-invasive ones do notControl cancer cellsCancer cells with CIRP deletedDark blue = cancer cellsBrain metastasis at diagnosis48 hours post-surgery3 months post-surgeryYellow Ring = brain metastasis. This example is from a lung cancer patient.