3 Main Roles of CoQ10 Mitochondrial energy - PowerPoint Presentation

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3 Main Roles of CoQ10

Mitochondrial energy

production

: important to make ATP (the energy our cells use)Stabilizes cell membrane: CoQ10 helps keep our cells healthy and regulates what comes in and goes out of the cell Antioxidant effect: tissues that produce a lot of energy tend to make a lot of free-radicals. So tissue like heart muscle and skeletal muscle are the tissues CoQ10 is found in highest concentration

E.

Sciatti

, C. Lombardi, A.

Ravera

, E.

Vizzardi

, I.

Bonade

, V.

Carubelli

, E.

Gorga

and M. Metra, "Nutritional Deficiency in Patients with Heart Failure.,"

Nutrients,

vol. 8, no. 7, 2016. [https://www.ncbi.nlm.nih.gov/pubmed/27455314].

How we get CoQ10

Made

in liver from amino acids

Obtained through diet (organ meat, poultry, fish are highest). Avg consumption 3-5 mg a day Supplemented

CoQ10 and Statins

Statins are cholesterol lowering drugs

Remember CoQ10 can be made in our liver

 statins stops that from happeningIf on a statin, take CoQ10

CoQ10 and Statins

It is well documented that Statin use depletes CoQ10 significantly

 meaning it must be replaced through supplementation

remember the actions of CoQ10: antioxidant, cell membrane protector, energy productionDeficiencies can lead to a number of problems Main symptoms of Statin induced CoQ10 deficiency: muscle fatigue, muscle damage (skeletal and cardiac muscle)https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55074/pdf/pnas01047-0254.pdf

Uses for CoQ10

Congestive Heart Disease, Coronary Heart Disease, Hypertension: 200 mg a day

Statin Use:

200 mg a dayMigraine Headaches: 150 mg a dayHelped with frequency and intensity of headaches (PMID: 11972582)Diabetes: 200 mg a dayEvidence showing T2DM linked to mitochondrial dysfunction, oxidation (CoQ10 helps with both)Helped reduce HgA1CFibromyalgia: 300 mg a day Helped with pain, fatigue, morning tiredness, tender points, recovery (PMID: 23458405)Exercise Tolerance (trained athletes): 100 mg a day Helped subjective fatigue sensation, physical performance (PMID: 18272335)

Additional Benefits:

Anti-inflammation: reduced CRP, IL-6, TNF-a (PMID 28179205)

Anti-oxidant

Key Buzzwords

Ubiquinone vs ubiquinol

Describing the chemical structure

Key Buzzwords

Ubiquinone vs ubiquinol

Biologic activity: no difference

(PMID 12069109)Bioavailability: ubiquinol is better (PMID 24979483, Q10facts.com)Absorption: ubiquinone is betterReally, ubiquinol gets converted into ubiquinone in the harsh stomach environment (Q10facts.com)OVERALL NO DIFFERENCE

Buzz Words

Oil based vs crystalline preparations

Must be oil or fat based, crystalline form is no good

Idebenone and MitoQBoth are new, up and coming products. Not currently available in retail stores in Canada (available online)MitoQ: CoQ10 with added positive charge. Supposedly has greater delivery to mitochondria. No human studies. Lots of good preclinical trials (in rats – liver dz, alzheimer’s, ALS, metaoblic syndrome)Idebenone: synthetic quinone – same class as CoQ10. Pharmaceutical version of CoQ10. No longer approved for

Alzherimers

as it was once meant for.

Their claim is CoQ10 requires functional mitochondria to work, whereas

Ibedenone

can work in even the worst mitochondrial health

Buzz Words

Source of CoQ10: Natural vs Synthetic

Natural = bacterial fermentation

 vast majority do this since its cheaper, effective processing Synthetic = CoQ10 made in a lab rarely done since its expensive Efficacy: No difference Price: natural is cheaper

Buzzwords

Vegan vs Non-Vegan CoQ10

Vegan source:

Agrobacterium tumefaciens (bacteria) fermentation Non- Vegan Source: usually meat

When to take

Best with fatty meal, hence some being encapsulated with oil (oil also serves to protect the molecule)

No difference of morning or evening administration

Nature’s Source/Signature Offerings