Web pollevcom ucibio Text To 37607 Type in 169964 ltyour questiongt Hormonal regulation The TCA The brain problem Most energy stored as fatty acids Brain only uses Glc ID: 401800
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Slide1
Lecture 22
Web: pollev.com/ucibio
Text:
To: 37607
Type in: 169964 <your question>Slide2
Hormonal regulationSlide3
The TCASlide4
The brain problem…
Most energy stored as fatty acids
Brain only uses
Glc
Fatty acids
Glc
?
How does brain function during starvation?Slide5
Production of ketone bodies
Starvation
Glycogen = 1 day
Amino acids
Glc
. BUT…
Muscles can use fatty acids (
need for
Glc
)
Gluconeogenesis
OAA, so
TCA
Without TCA, liver makes “Ketone bodies” from fatsSlide6
Ketone bodiesSlide7
Diabetes & ketone bodies
Starvation
KB Used by brain
Extreme starvation
Muscle breakdown
No insulin
Blood sugar, AND
FA breakdown
Too much Acetyl CoA
Ketone bodies
Brain has plenty of
Glc
!
Ketone bodies in blood =
pH
Death
Slide8
If only…Slide9
Making fatty acids = adding 2 Cs to chain!Slide10
AcCoA
Malonyl
CoASlide11
ACP in FASSlide12
FASSlide13
FASSlide14
Fatty acid synthesisSlide15
Substrate shuttling in FASSlide16
Substrate shuttling in
FASSlide17
Further steps…Slide18
Further steps…Slide19
Regulation of FAS & breakdownSlide20
Allosteric regulation of ACC