B cells NK cells Tc cells Th cells 2 Which of the following statement refer to T cells When activated they produce a secreted form of their antigenrecognition molecule Their ID: 915016
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Slide1
1. Which cell type can differentiate into an antibody producing plasma cells?
B cells NK cellsTc cellsTh cells
Slide22. Which of the following statement refer to T cells
?When activated, they produce a secreted form of their antigen-recognition molecule.Their antigen receptors are composed of two heavy chains and two light chains.
They recognize epitopes of native antigen.They bind to antigen peptides associated with HLA proteins.
Slide33. The class of immunoglobulin that is transported across the placenta from mother to foetus
isIgA IgDIgE
IgGIgM
Slide44. Which of the following factors has not been associated with the development of autoimmune disease:
Sex HLA Genetic factors other than HLA
InfectionSCID
Slide55. Ankylosing spondylitis is strongly associated with HLA-
:B8DR3DR4B27
DR2
Slide66. Which of the following is a non-organ-specific (systemic) autoimmune disease
:Myasthenia gravisSystemic lupus erythematosus (SLE)Hashimoto's thyroiditis
Pernicious anemiaInsulin-dependent diabetes mellitus
Slide77. HLA-DR2 is a risk factor for
:Multiple sclerosisInsulin-dependent (type I) diabetesAnkylosing spondylitisRheumatoid
arthritisMyasthenia gravis
Slide88. Exophthalmos is often associated with
:Hashimoto's diseasePrimary myxedemaGraves' disease
Idiopathic thrombocytopenic purpuraAutoimmune hemolytic anemia
Slide99. Neonatal myasthenia gravis is thought to be caused by
:An inherited genetic defectTransplacental transfer of maternal IgG against the TSH receptorAnti-idiotype
to maternal IgGTransplacental transfer of maternal IgG against the acetylcholine receptor
Maternal T-cells transferred across the placenta
Slide1010. In type 1 diabetes (insulin-dependent diabetes mellitus), the target of the autoimmune attack is:
All of the cells in the islets of LangerhansThe β-cells in the islets of Langerhans
The somatostatin-producing cells in the islets of LangerhansThe glucagon-producing cells in the islets of Langerhans
Cells throughout the body which have an insulin receptor
Slide1111. A therapeutic approach in rheumatoid arthritis is to
:Stimulate TNF (TNFa) productionInhibit TNF (TNFa) activity
Reduce TGFb secretionAdminister silver salts
Use prostaglandin
Slide1212. A difference between organ-specific and
nonorgan-specific autoimmune disorders is that:Only in organ-specific autoimmune disorders is there a greater incidence in womenAssociations with HLA are only seen in nonorgan-specific autoimmunity
Circulating autoantibodies react with normal body components only in organ-specific autoimmune disordersIt is only in organ-specific autoimmune disorders that autoantibody tests are of diagnostic
valueOnly in
nonorgan
-specific autoimmune diseases are anti-nuclear antibodies a frequent feature