T paraluiscuniculi Cuniculi A T phagedenis DSM18690 T phagedenis Reiter T vincentii F0403 T medium DSM18689 T medium ATCC700293 T pedis DSM18691 T pedis ID: 1007582
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1. Figure 1T. pallidum str. NicholsT. paraluiscuniculi Cuniculi AT. phagedenis DSM18690T. phagedenis ReiterT. vincentii F0403T. medium DSM18689 T. medium ATCC700293T. pedis DSM18691T. pedis str. T A4T. denticola ATCC35405T. putidum ATCC 700334T. maltophilum ATCC51939T. socranskii ATCC35535T. ruminis DSM103462T. rectale DSM103679T. succinifaciens DSM489T. caldarium DSM 7334T. bryantii NK4A124T. azotonutricium ZAS9T. primitia ZAS20.020BAT. medium DSM18689 T. medium ATCC700293T. vincentii F0403T. phagedenis DSM18690T. phagedenis ReiterT. pedis DSM18691T. pedis str. T A4T. denticola ATCC35405T. putidum ATCC 700334T. maltophilum ATCC51939T. socranskii ATCC35535T. rectale DSM103679T. succinifaciens DSM489T. bryantii NK4A124T. ruminis DSM103462T. pallidum str. NicholsT. paraluiscuniculi Cuniculi AT. caldarium DSM 7334T. azotonutricium ZAS9T. primitia ZAS20.050Bovine digital dermatitis clusterBovine gastro-intestinal clusterSyphilis clusterBovine digital dermatitis / Syphilis cluster
2. ABFigure 2ECD
3. Figure 3ACB
4. PhoRPhoU IS5/IS1182 family transposasePhoBPstBPstAPstCPstSTranscriptional regulatorMethyl accepting chemotaxis protein transposaseNC domain proteinNot present in bovine USA isolateWbpA/WbpOWbuBWecBGlycosyl transferaseWzxCNAD(P) – dependant oxidoreductaseATP grasp domain containing proteinWecERfbaWbpD/WlbB Nucleotidyltransferase WbpE/WlbCDUF86 domain-contain-ing proteinWbpB/ WlbAFigure 4AB
5. Figure 5AB
6. Figure 6Relative OD (%)AB***Treponema phagedenis Strain
7. Supplementary Figure 1 T. medium ATCC 700293 T. medium T19 Treponema sp. OMZ 838 T. vincentii ATCC 35580 T. vincentii F0403 T. phagedenis Reiter T. phagedenis T320AT. pedis T A4 T. pedis T3552BT T. putidum OMZ 758 T. denticola ATCC 33520 T. denticola ATCC 35404 T. azotonutricium ZAS-9 T. primitia ZAS-2 T. caldarium DSM 7334 T. lecithinolyticum ATCC 700332 T. maltophilum ATCC 51939T. brennaborense DSM 12168 T. socranskii subsp. Socranskii ATCC 35536 T. bryantii NK4A124 Treponema sp. JC4 T. porcinum strain ATCC BAA908 T. succinfaciens DSM 2489 T. saccharophilum DSM 2985 T. ruminis T. berlinense ATCC BAA-909 T. pectinovorum Marseille-1T. paraluiscuniculi Cuniculi AT. pallidum subsp. pallidum. NicholsT. pallidum subsp. pallidum. Sea 81-49210010010010010010010010010010010010010010037651009696100100100100851000.03
8. CitDCitFCitECitrate-sodium symporterType III endonucleaseRecombinasePresent in all including humanSite specific DNA methyl transferaseATP Binding ProteinFibron-ectin binding proteinABC transporterEcfTTetR/AcrR transcriptional regulatorCell filamentation protein FicClass 1 SAM dependent methyl transferaseN-acetyl transferaseCell filamentation protein FicMethyl-transferaseTraG/ TraD/ VirD4 bacterial conjugation proteinDNA Topoisomerase IIIAbrB/ MazE/ SpoVT family DNA binding protein containing proteinClass 1 SAM dep-endent methyl transferaseConjugal transfer proteinXRE transcriptional reg-ulatorSite specific DNA methyl transferaseDNA cytosine methyl transferaseCell filamentation protein FicCitDCitFCitECitrate-sodium symporterType III endonucleaseRecombinasePresent in all including humanSite specific DNA methyl transferaseABC transporterEcfTTetR/AcrR transcriptional regulatorCell filamentation protein FicClass 1 SAM dependent methyl transferaseN-acetyl transferaseCell filamentation protein FicMethyl-transferaseTraG/ TraD/ VirD4 bacterial conjugation proteinDNA Topoisomerase IIIAbrB/ MazE/ SpoVT family DNA binding protein containing proteinClass 1 SAM dep-endent methyl transferaseConjugal transfer proteinXRE transcriptional reg-ulatorSite specific DNA methyl transferaseDNA cytosine methyl transferaseCell filamentation protein FicSupplementary Figure 2duf4868AB