HEALTHY WAY TO HEALTHY LIFE Dr ARMINDER KAUR Associate Professor School of Basic amp Applied Sciences Department of Biotechnology Sanskriti University Mathura UP India Poor nutritional response ID: 1012271
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1. VIRTUAL CLASSROOM 2020PROBIOTIC FOODS HEALTHY WAY TO HEALTHY LIFEDr. ARMINDER KAURAssociate Professor,School of Basic & Applied Sciences, Department of Biotechnology, Sanskriti University, Mathura (U.P.), India.
2. Poor nutritional response Reduced efficacy of medications Physiological dysfunction Accelerated aging Cancer Deficient immune response Susceptibility to infection Physical discomfort Imbalance of intestinal micro flora
3. INTESTINE IS A PARADISE OFDISEASES“Death sits in thebowels; a baddigestion is theroot of all evil” -Hippocrates, ca.400 BC
4. Probiotic - (for life) It is defined as “A substance that contains microorganisms or bacteria that are beneficial to the host organism.”
5. SafetyOrigin Functional aspects Survival Adherence, colonisation Anti-microbial products Immune stimulationGenetic stable Prevention of pathogensSelection of Probiotic organism
6. HISTORY OF PROBIOTICSBulgarian yoghurt (sour milk), commonly consumed plain, is popular for its taste, aroma, and quality. The qualities arise from the Lactobacillus bulgaricus and Streptococcus thermophilus culture strains used in Bulgaria.In 1907 Metchnikoff proposed that the acid producing bacteria in fermented milk products could prevent“fouling" in the large intestine and, if consumedregularly, lead to a longer, healthier life.
7. HISTORY OF PROBIOTICS- 1930’SIn early 1930’s, in Japan, Minoru Shirota developed a fermented milk product called YakultIn 1935 he started marketing Yakult as a probiotic yogurt-like product made by fermenting a mixture of skimmed milk with a special strain of Lactobacillus casei shirota
8. HISTORY OF PROBIOTICS- 1965• Probiotics term coined in 1965 by Lilly and Stillwell.• Probiotics defined as microorganisms that have a beneficial effect on the host intestinal microbial Balance.• Probiotics, which means “for life” was meant to contrast “antibiotics”, popularly prescribed and known to also destroy beneficial organisms and impact the immune system.
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14. Factors affecting the intestinal micro ecosystemAny action taken to kill ‘bad’ bacteria essentially kills ‘good’ bacteria as well. Antibiotics and other drugs intake Microbial infections Diet (highly processed, low-fiber foods) Chronic diarrhea Stress
15. Non-pathogenic, non-toxic and non-allergic.Capable of surviving and metabolizing in upper G.I. tract secretion in the gut environment e.g.Resistant to low pH, organic acids, bile juice, saliva and gastric acid.Genetically stable and capable of remaining viable for long periods in field condition. Modulate immune response and provide resistance to disease through improved immunity or by the production of antimicrobial substance in the guts.(…..contd.) Properties of microbe as a Probiotic
16. Advantages of ProbioticsProduce lactic acid- lowers the pH of intestines and inhibiting bacterial villains such as Clostridium, Salmonella, Shigella, E. coli, etc.Decreases the production of a variety of toxic or carcinogenic metabolites.Aid absorption of minerals, especially calcium, due to increased intestinal acidity.Production of β- D- galactosidase enzymes that break down lactose .
17. Antibiotic associated diarrhea Disease Antibiotic treatment Diarrhea Disturbance of intestinal microbiota Clostridium overgrowth produces toxin
18. Therapeutic role of Probiotic in Antibiotic associated diarrhea Disease Antibiotic treatment Probiotics Disturbance of intestinal microbiota Microbiota Clostridium overgrowthin balance produces toxin
19. EFFECTS OF PROBIOTICSGood adhesion/ colonization to human intestinal tract Antagonistic against carcinogenic/ pathogenic organism.Posses clinically proven health benefit, e.g. gastrointestinal disorders, persistant diarrhoea, clostridium difficle colitis, antibiotics associated diarrhoea, acute infantile gastroenteritis etc.Properties for commercial viability such as stability of desired characteristics during processing, storage and transportation.
20. PROBIOTIC RESEARCH• Allergies - certain probiotics have an impact on the mucosal barrier function of the intestinal tract. This effects allergens entering the body and the activity of inflammation producing cells.• Cholesterol – regular consumption of certain probiotic dairy products may have an impact on cholesterol level and may affect the levels of ― good HDL in the blood• Colon Cancer – Certain probiotics may help prevent colon cancer by preventing the breakdown of enzymes that contribute to the growth of cancer causing agents.
21. BENEFITS OF PROBIOTICS TO INFANTSInfant Health – Mother nature has long recognized the benefits of Probiotics. Human breast milk contains a protein that stimulates the growth of good bacteria to help with digestion. Therefore a way to create and maintain a perfect balance of gut bacteria in babies has been in existence for as long as babies have been born• Probiotics in Infant Formulas with the added protective - benefit of beneficial probiotic cultures like those naturally promoted by breast milk, help support Baby’s healthy immune system. High levels of Bifidobacteria in the digestive tract are thought to be one of the reasons why breastfed babies are generally so healthy.
22. RECENT TRENDS IN PROBIOTIC RESEARCHContinued clinical research to study the benefits of probiotics in the areas of :• Obesity and Weight Management (exopolysaccharideproducing probiotic strains)• Prevention of osteoporosis (improved bioavailabilityand absorption of nutrients)• Growth development in children (improved bioavailability and absorption of nutrients)• Treating and preventing respiratory infections, specially in children (boost immune system)
23. A total of 169 Lactobacillus strains from 12 species (L. acidophilus, L. brevis, L. buchneri, L. casei, L. delbrueckii subsp. bulgaricus, L. delbrueckii subsp. delbrueckii, L. delbrueckii subsp. lactis, L. fermentum, L. helveticus, L. paracasei subsp. paracasei, L. plantarum and L. rhamnosus) isolated from raw milk and various milk products.Commonly used Probiotic Strains
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