Assistant Professor SBMU اسلاید عملی 8 Prostatic hyperplasia June 14 2020 2 Sample footer Benign prostatic hyperplasia BPH benign enlargement of the prostate June 14 2020 Sample footer ID: 927978
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T. Mollasharifi Anatomical & Clinical Pathologist Assistant Professor, SBMU
اسلاید عملی 8
Slide2Prostatic hyperplasia June 14, 20202Sample footer
Slide3Benign prostatic hyperplasia (BPH), benign enlargement of the prostateJune 14, 2020Sample footer3
Slide4hyperplasia of prostatic stromal and epithelial cells resulting in the formation of large, fairly discrete nodules in the periurethral region of the prostate. June 14, 2020Sample footer
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Slide5When sufficiently large, the nodules compress the urethral canal to cause partial, or sometimes complete, obstruction of the urethra, which interferes with the normal flow of urine
Slide6normal prostate gland is about 3 to 4 cm in diameter. This prostate is enlarged due to prostatic hyperplasia, which appears nodular. Thus, this condition is termed either BPH (benign prostatic hyperplasia) or nodular prostatic hyperplasia.
Slide7Benign prostatic hyperplasia.
Slide8Slide9Nodular prostatic hyperplasia. Well-defined nodules compressthe urethra into a slitlike lumen.
Slide10Normal glandsJune 14, 2020Sample footer10
Slide11Corpora amylaceaJune 14, 2020Sample footer11
Slide12This benign gland contains corpora amylacea. Even at low magnification, basal cells can be clearly seen. June 14, 2020Sample footer12
Slide13Benign prostatic hyperplasia can involve both glands and stroma, though the former is usually more prominent. Here, a large hyperplastic nodule of glands is seen.
Slide14the enlarged prostate has glandular hyperplasia.
Slide15Slide16Prostatic adenocarcinomaJune 14, 202016Sample footer
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Slide18These sections through a prostate removed via radical prostatectomy reveal irregular yellowish nodules.This proved to be prostatic adenocarcinoma. Prostate glands containing adenocarcinoma are not necessarily enlarged.June 14, 2020Sample footer
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Slide19Adenocarcinoma may also coexist with hyperplasia. prostatic hyperplasia is not a premalignant lesion.
Slide20The glands typically are smaller than benign glands and are lined by a single uniform layer of cuboidal or low columnar epithelium, lacking the basal cell layer seen in benign glands. Malignant glands are crowded together and characteristically lack branching and papillary infolding. Nuclei are enlarged and often contain one or more prominent nucleoli
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Slide22At high magnification, the neoplastic glands of prostatic adenocarcinoma are still recognizable as glands, but there is no intervening stroma and the nuclei are hyperchromaticJune 14, 2020Sample footer22
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Slide24SeminomaJune 14, 202024Sample footer
Slide25Seminoma is a germ cell tumor(cancer) of the testis. It is one of the most treatable and curable cancers, with survival >95% in the early stagesJune 14, 2020Sample footer25
Slide26Seminoma originates in the germinal epitheliumof the seminiferous tubulesAbout half of germ cell tumors of the testis are seminomasJune 14, 2020Sample footer
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Slide27Here is a normal testis and adjacent structures. Identify the body of the testis, epididymis, and spermatic cord.
Slide28The mass lesion seen here in the testis is a seminoma. Germ cell neoplasms are the most common types of testicular neoplasm. They are most common in the 15 to 34 age group. They often have several histologic components: seminoma, embryonal carcinoma, teratoma, choriocarcinoma. The one that is most likely to be of one histologic type is seminoma, as in the testis seen here.
Slide29Here is a seminoma that is larger yet. Normal testis appears to the left of the mass, and the spermatic cord extends to the left of that. The tumor is composed of lobulated soft tan tissue.
Slide30Seminoma presents as a soft, well-demarcated, gray-white tumor that bulges from the cut surface of the affected testis
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Slide32Note the orderly maturation of germ cells from the base to the center of the lumen. Spermatogonia (along the basement membrane), primary & secondary spermatocytes, spermatids, and spermatozoa are seenJune 14, 2020Sample footer32
Slide33Seminoma composed of large, uniform cells with distinct cell borders, clear, glycogen-rich cytoplasm,round nuclei, and conspicuous nucleoli .The cellsoften are arrayed in small lobules with intervening fibrous septa.A lymphocytic infiltrate usually is present.
Slide34This is the histologic pattern of the typical seminoma. Lobules of neoplasitic cells have an intervening stroma with characteristic lymphoid infiltrates. The seminoma cells are large with vesicular nuclei, and pale watery cytoplasm.
Slide35Note the lymphocytic infiltrate surrounding clusters of tumor cells creating a pseudoglandular appearance.June 14, 2020Sample footer35
Slide36The cytoplasm of seminoma cells is usually clear to lightly eosinophilic. The cytoplasmic clearing is due to glycogen content which can be demonstrated by PAS positivity. The nuclei are round to oval with granular chromatin and prominent nucleoliJune 14, 2020Sample footer36