Anne Campbell 1232014 Polycystic Kidney Disease Genetic Disease Normal kidney tissue is replaced with fluid filled cysts 600K People suffer from PKD Characteristics of PKD Enlargement of the Kidneys ID: 1045281
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1. Polycystic Kidney DiseaseAnne Campbell1.23.2014
2. Polycystic Kidney DiseaseGenetic DiseaseNormal kidney tissue is replaced with fluid filled cysts600K People suffer from PKD
3. Characteristics of PKDEnlargement of the KidneysFormation of fluid filled cystsPain
4. Characteristics of PKDRenal FailureComplications with other organs2 types of PKD
5. Recessive vs. Dominant RareInfantileMust inherit 2 copies to express symptoms25% chanceCommon type of PKDAdult PKDCan inherit from a single parent50% chanceAutosomal Recessive PKDAutosomal Dominant PKD
6. Autosomal Dominant PKD10% of cases arise spontaneouslySymptoms appear around 20-30 years of age20-30 lb kidneys No cure, treat symptoms (high blood pressure, pain)
7. Autosomal Recessive PKDSigns can begin before birthEnlarged, abnormal kidneysDevelopmental issuesKidney failure early onLiver scarring- worsens with ageNo cure, treat symptomsWorse cases- live only hours or days
8. Genetics of PKDAutosomal Dominant: PKD1 and PKD2 (chr.16 and chr.4)Polycystin-1 and polycystin-2 Autosomal Recessive: PKDH1 (chr.6)
9. Referenceshttp://sonoworld.com/fetus/page.aspx?id=2100http://kidney.niddk.nih.gov/kudiseases/pubs/polycystic/#genetichttp://www.mayoclinic.org/diseases-conditions/polycystic-kidney-disease/basics/causes/con-20028831