Coverimage - PDF document

1 Coverimage: Picturedisascanning electron
Coverimage: Picturedisascanning electronmicrographofthenectaryeast Metschnikowiareukaufii inthefloral tubeoftheplant Mimulusaurantiacus . AndrewD.Lettenetal.conducted microcosmexperimentsandused simulationmodelstoexaminehow variabilityinenvironmentalconditions influencesspeciescoexistenceinnectar yeast.Theauthorsfoundthatthe modelspredictedtheoutcomesofthe mixed-culturecompetitionexperiments with83%accuracyandrevealed mechanismsthatwerecriticalfor maintainingfloralmicrobialdiversity. SeethearticlebyLettenetal.onpages 6745 – 6750.ImagecourtesyofManpreet K.Dhami,CissyPan(LandcareResearch, Lincoln,NewZealand),andLydia-Marie Joubert(StellenboschUniversity, SouthAfrica). FromtheCover 6745Environmentalvariabilityandspeciescoexistence 6644Futurewarmingandmaizeproduction 6739Fossilresinsandarthropodpaleocommunities 6810Transcriptomeregulationinprostatecancer 6834Screenforbiogenesisinhibitors Contents THISWEEKINPNAS 6513InThisIssue LETTERS(ONLINEONLY) E5840Historybythenumbers? NickTosh,JohnFerguson,andCathalSeoighe E5841ReplytoToshetal.:Quantitativeanalysesofculturalevolutionrequire engagementwithhistoricalandarchaeologicalresearch ThomasE.Currie,PeterTurchin,HarveyWhitehouse,PieterFranc ¸ois,KevinFeeney,Daniel Mullins,DanielHoyer,ChristinaCollins,StephanieGrohmann,PatrickSavage,Gavin Mendel-Gleason,EdwardTurner,AgatheDupeyron,EnricoCioni,JennyReddish,Jill Levine,GreineJordan,EvaBrandl,AliceWilliams,RudolfCesaretti,MartaKrueger, AlessandroCeccarelli,JoeFigliulo-Rosswurm,Po-JuTuan,PeterPeregrine,Arkadiusz Marciniak,JohannesPreiser-Kapeller,NikolayKradin,AndreyKorotayev,AlessioPalmisano, DavidBaker,JulyeBidmead,PeterBol,DavidChristian,ConnieCook,AlanCovey,Gary Feinman,A ´ rniDan ´ elJu ´ l ´ usson,AxelKristinsson,JohnMiksic,RuthMostern,Cameron Petrie,PeterRudiak-Gould,BarendterHaar,VesnaWallace,VictorMair,LiyeXie,John Baines,ElizabethBridges,JosephManning,BruceLockhart,AmyBogaard, andCharlesSpencer E5843ExpansionoftheIL1Bgenefamilyinthepig Ji-LongLiu,MiaoZhao,Wen-QianZhang,andMing-YuHuang E5845Noevidencethatextinctionriskincreasesinthelargestand smallestvertebrates DanielPincheira-DonosoandDaveJ.Hodgson E5847ReplytoPincheira-DonosoandHodgson:Boththelargestandsmallest vertebrateshaveelevatedextinctionrisk WilliamJ.Ripple,ChristopherWolf,ThomasM.Newsome,MichaelHoffmann,AaronJ. Wirsing,andDouglasJ.McCauley SCIENCEANDCULTURE — Howscienceintersectswithculture 6515Mathtoolssendlegislatorsbacktothedrawingboard StephenOrnes INNERWORKINGS — Anover-the-shoulderlookatscientistsatwork 6518Theracetopatchthehumanheart CarolynBeans FreeonlinethroughthePNASopenaccessoption.PNAS u June26,2018 u vol.115 u no.26 u iii – viii June26,2018 u vol.115 u no.26 QNAS 6521QnAswithMarkHay BrianDoctrow 6523QnAswithRafaelRadi SandeepRavindran SeeInauguralArticleonpage5839inissue23ofvolume115 COMMENTARIES 6525Samplingtheinsectsoftheamberforest DerekE.G.Briggs Seecompanionarticleonpage6739 6528HoxB13mediatesAR-V7activityinprostatecancer He ´ctorI.NavarroandAndrewS.Goldstein Seecompanionarticleonpage6810 6530Goingonoffenseagainstthegram-negativedefense BryonS.DrownandPaulJ.Hergenrother Seecompanionarticleonpage6834 PNASPLUS 6533SignificanceStatements Briefstatementswrittenbytheauthorsaboutthesignificanceoftheir papers. INAUGURALARTICLE 6538Monitoringmolecularnonadiabaticdynamicswith femtosecondX-raydiffraction KochiseBennett,MarkusKowalewski,Je ´re ´myR.Rouxel, andShaulMukamel PHYSICALSCIENCES APPLIEDMATHEMATICS 6548 Riverlandscapesandoptimalchannelnetworks PaulBalister,Jo ´zsefBalogh,EnricoBertuzzo,Be ´laBolloba ´s, GuidoCaldarelli,AmosMaritan,RossanaMastrandrea,Robert Morris,andAndreaRinaldo APPLIEDPHYSICALSCIENCES 6554 Howtobetterfocuswavesbyconsideringsymmetry andinformationloss KaiLou,SteveGranick,andFranc ¸oisAmblard 6560Squeezingandstick – slipfrictionbehaviorsof lubricantsin

2 boundarylubrication Rong-GuangXuandYongs
boundarylubrication Rong-GuangXuandYongshengLeng 6566 Electron  holeseparationinferroelectricoxidesfor efficientphotovoltaicresponses DonghoonKim,HyeonHan,JuneHoLee,JinWooChoi, JeffreyC.Grossman,HyunMyungJang,andDonghunKim BIOPHYSICSANDCOMPUTATIONALBIOLOGY E5849 Ontheroleofsidechainsizeandchargeinthe aggregationofA
42withfamilialmutations XiaotingYang,GeorgMeisl,BirgittaFrohm,EvaThulin, TuomasP.J.Knowles,andSaraLinse 6572StochasticTuringpatternsinasynthetic bacterialpopulation DavidKarig,K.MichaelMartini,TingLu,NicholasA.DeLateur, NigelGoldenfeld,andRonWeiss 6578Efficientencapsulationofproteinswith randomcopolymers TrungDacNguyen,BaofuQiao,andMonicaOlveradelaCruz 6584All-atomsimulationsdisentanglethefunctional dynamicsunderlyinggenematurationinthe intronlariatspliceosome LorenzoCasalino,GiuliaPalermo,AngeloSpinello,Ursula Rothlisberger,andAlessandraMagistrato CHEMISTRY E5859EnhancedmRNAdeliveryintolymphocytesenabled bylipid-variedlibrariesofcharge-altering releasabletransporters ColinJ.McKinlay,NancyL.Benner,OleA.Haabeth,RobertM. Waymouth,andPaulA.Wender E5867NMRchemicalshiftanalysisdecodesolefinoligo- andpolymerizationactivityofd 0 group4 metalcomplexes ChristopherP.Gordon,SatoruShirase,Keishi Yamamoto,RichardA.Andersen,OdileEisenstein, andChristopheCope ´ret E5877 Directobservationandrationaldesignofnucleation behaviorinaddressableself-assembly MartinSajfutdinow,WilliamM.Jacobs,AleksReinhardt, ChristophSchneider,andDavidM.Smith E5896Chemoproteomicsrevealsbaicalinactivateshepatic CPT1toamelioratediet-inducedobesityand hepaticsteatosis JianyeDai,KaiLiang,ShanZhao,WentongJia,Yuan Liu,HongkunWu,JiaLv,ChenCao,TaoChen,Shentian Zhuang,XiaomengHou,ShijieZhou,XiannianZhang,Xiao-Wei Chen(


),YanyiHuang,Rui-PingXiao,Yan-LingWang, TuopingLuo,JunyuXiao,andChuWang 6538Monitoringmolecularnonadiabaticdynamicswith femtosecondX-raydiffraction KochiseBennett,MarkusKowalewski,Je ´re ´myR.Rouxel, andShaulMukamel 6590Brightquantumdotsemittingat  1,600nm intheNIR-IIbwindowfordeeptissue fluorescenceimaging MingxiZhang,JingyingYue,RanCui,ZhuoranMa,HaoWan, FeifeiWang,ShoujunZhu,YingZhou,YunKuang,Yeteng Zhong,Dai-WenPang,andHongjieDai EARTH,ATMOSPHERIC,ANDPLANETARYSCIENCES 6596Thalliumisotopesrevealprotractedanoxia duringtheToarcian(EarlyJurassic) associatedwithvolcanism,carbonburial, andmassextinction TheodoreR.ThemII,BenjaminC.Gill,AndrewH.Caruthers, AngelaM.Gerhardt,DarrenR.Gro ¨ cke,TimothyW.Lyons, SelvaM.Marroqu ´ n,SuneG.Nielsen,Joa ˜ oP.Trabucho Alexandre,andJeremyD.Owens 6602OxygenisotopecompositionofthePhanerozoic oceanandapossiblesolutiontothe dolomiteproblem UriRybandJohnM.Eiler 6608 Multiplegenerationsofgrainaggregationin differentenvironmentsprecededsolar systembodyformation HopeA.Ishii,JohnP.Bradley,HansA.Bechtel,DonaldE. Brownlee,KarenC.Bustillo,JamesCiston,JeffreyN.Cuzzi, ChristineFloss,andDavidJ.Joswiak iv u www.pnas.org Contents ENGINEERING E5887High-speedmicrojetsissuefromburstingoilgland reservoirsofcitrusfruit NicholasM.Smith,HosseinEbrahimi,RanajayGhosh, andAndrewK.Dickerson E5926 Microfluidicchambersusingfluidwallsfor cellbiology CristianSoitu,AlexanderFeuerborn,AnnNaTan,Henry Walker,PatA.Walsh,AlfonsoA.Castrejo ´n-Pita,PeterR.Cook, andEdmondJ.Walsh 6614Ahigh-efficiencyregimeforgas-phase terahertzlasers FanWang,JeongwonLee,DaneJ.Phillips,SamuelG. Holliday,Song-LiangChua,JorgeBravo-Abad,JohnD. Joannopoulos,MarinSolja
ci  c,StevenG.Johnson, andHenryO.Everitt 6620Confiningelectrodepositionofmetalsin structuredelectrolytes SnehashisChoudhury,DuylinhVu,AlexanderWarren,MukulD. Tikekar,ZhengyuanTu,andLyndenA.Archer 6626Unveilingthehigh-activityoriginofsingle-atomiron catalystsforoxygenreductionreaction LiuYang,DaojianCheng,HaoxiangXu,XiaofeiZeng,XinWan, JianglanShui,ZhonghuaXiang,andDapengCao 6632Microscaleoptoelect

3 ronicinfrared-to-visible upconversiondev
ronicinfrared-to-visible upconversiondevicesandtheiruseas injectablelightsources HeDing,LihuiLu,ZhaoShi,DanWang,LizhuLi,XichenLi,Yuqi Ren,ChangboLiu,DaliCheng,HoyeonKim,NoelC.Giebink, XiaohuiWang,LanYin,LingyunZhao,MinminLuo, andXingSheng 6638 Shapingreverberatingsoundfieldswithanactively tunablemetasurface GuancongMa,XiyingFan,PingSheng,andMathiasFink 6685Combinatorialdrugdiscoveryinnanoliterdroplets AnthonyKulesa,JaredKehe,JuanE.Hurtado,PriancaTawde, andPaulC.Blainey ENVIRONMENTALSCIENCES 6644Futurewarmingincreasesprobabilityofglobally synchronizedmaizeproductionshocks MichelleTigchelaar,DavidS.Battisti,RosamondL.Naylor, andDeepakK.Ray 6733Allometricscalingofestuarine ecosystemmetabolism NicholasJ.Nidzieko PHYSICS 6650Biologicaltissue-inspiredtunablephotonicfluid XinzhiLi,AmitDas,andDapengBi(


) 6656Randomcriticalpointseparatesbrittleandductile yieldingtransitionsinamorphousmaterials MisakiOzawa,LudovicBerthier,GiulioBiroli,AlbertoRosso, andGillesTarjus 6662 Isotropic,nematic,andlamellarphasesincolloidal suspensionsofnanosheets PatrickDavidson,ChristophePenisson,DoruConstantin, andJean-ChristopheP.Gabriel SUSTAINABILITYSCIENCE 6751Widespreadlossofintermediatesoilhorizonsin urbanlandscapes DustinL.Herrmann,LauraA.Schifman,andWilliamD.Shuster 6804Effectofenvironmentalchangesonvegetableand legumeyieldsandnutritionalquality PaulineF.D.Scheelbeek,FrancesA.Bird,HannaL.Tuomisto, RosemaryGreen,FrancescaB.Harris,EdwardJ.M.Joy,Zaid Chalabi,ElizabethAllen,AndyHaines,andAlanD.Dangour SOCIALSCIENCES POLITICALSCIENCES 6668 SMStextsoncorruptionhelpUgandanvotershold electedcouncillorsaccountableatthepolls MarkT.Buntaine,RyanJablonski,DanielL.Nielson, andPaulaM.Pickering PSYCHOLOGICALANDCOGNITIVESCIENCES 6674Flynneffectanditsreversalareboth environmentallycaused BerntBratsbergandOleRogeberg SUSTAINABILITYSCIENCE 6644Futurewarmingincreasesprobabilityofglobally synchronizedmaizeproductionshocks MichelleTigchelaar,DavidS.Battisti,RosamondL.Naylor, andDeepakK.Ray BIOLOGICALSCIENCES AGRICULTURALSCIENCES 6679 Genomicandenvironmentaldeterminantsandtheir interplayunderlyingphenotypicplasticity XinLi,TingtingGuo,QiMu,XianranLi,andJianmingYu APPLIEDBIOLOGICALSCIENCES E5859EnhancedmRNAdeliveryintolymphocytesenabled bylipid-variedlibrariesofcharge-altering releasabletransporters ColinJ.McKinlay,NancyL.Benner,OleA.Haabeth,RobertM. Waymouth,andPaulA.Wender 6685Combinatorialdrugdiscoveryinnanoliterdroplets AnthonyKulesa,JaredKehe,JuanE.Hurtado,PriancaTawde, andPaulC.Blainey BIOCHEMISTRY E5896Chemoproteomicsrevealsbaicalinactivateshepatic CPT1toamelioratediet-inducedobesityand hepaticsteatosis JianyeDai,KaiLiang,ShanZhao,WentongJia,Yuan Liu,HongkunWu,JiaLv,ChenCao,TaoChen,Shentian Zhuang,XiaomengHou,ShijieZhou,XiannianZhang,Xiao-Wei Chen(


),YanyiHuang,Rui-PingXiao,Yan-LingWang, TuopingLuo,JunyuXiao,andChuWang E5906ConformationalcontrolandDNA-binding mechanismofthemetazoanorigin recognitioncomplex FranziskaBleichert,AlexanderLeitner,RuediAebersold, MichaelR.Botchan,andJamesM.Berger 6691 Lipidbindingattenuateschannelclosureoftheouter membraneproteinOmpF IdlirLiko,MatteoT.Degiacomi,SejeongLee,ThomasD. Newport,JosephGault,EamonnReading,JonathanT.S. Hopper,NicholasG.Housden,PaulWhite,MatthewColledge, AltinSula,B.A.Wallace,ColinKleanthous,PhillipJ.Stansfeld, HaganBayley,JustinL.P.Benesch,TimothyM.Allison, andCarolV.Robinson Contents PNAS u June26,2018 u vol.115 u no.26 u v 6697 Anarchaealprimasefunctionsasananoscalecaliper todefineprimerlength JiangyuYan,SandroHolzer,LucaPellegrini, andStephenD.Bell BIOPHYSICSANDCOMPUTATIONALBIOLOGY E5916 Flagellumcouplescellshapetomotilityin Trypanosomabrucei StellaY.Sun,JasonT.Kaelber,MuyuanChen,XiaoduoDong, YasamanNematbakhsh,JianShi,MatthewDougherty, ChweeTeckLim,MichaelF.Schmid,WahChiu, andCynthiaY.He 6650Biologicalti

4 ssue-inspiredtunablephotonicfluid Xinzhi
ssue-inspiredtunablephotonicfluid XinzhiLi,AmitDas,andDapengBi(


) 6703 Uniquefunctionwordscharacterize genomicproteins AndreaScaiewiczandMichaelLevitt 6709StructureandmutagenicanalysisofthelipidII flippaseMurJfrom Escherichiacoli SanduoZheng,Lok-ToSham,FrederickA.Rubino,KellyP. Brock,WilliamP.Robins,JohnJ.Mekalanos,DeboraS.Marks, ThomasG.Bernhardt,andAndrewC.Kruse CELLBIOLOGY E5926 Microfluidicchambersusingfluidwallsfor cellbiology CristianSoitu,AlexanderFeuerborn,AnnNaTan,Henry Walker,PatA.Walsh,AlfonsoA.Castrejo ´n-Pita,PeterR.Cook, andEdmondJ.Walsh E5934Suppressionofconnexin43phosphorylation promotesastrocytesurvivalandvascular regenerationinproliferativeretinopathy NefeliSlavi,AbduqodirH.Toychiev,StylianosKosmidis, JessicaAckert,StewartA.Bloomfield,HeikeWulff,Suresh Viswanathan,PaulD.Lampe,andMiduturuSrinivas E5944RegulationofadistinctactivatedRIPK1intermediate bridgingcomplexIandcomplexIIinTNF
- mediatedapoptosis PalakAmin,MarcusFlorez,AyazNajafov,HelingPan,Jiefei Geng,DimitryOfengeim,SlawomirA.Dziedzic,Huibing Wang,VicaJeanBarrett,YasushiIto,MatthewJ.LaVoie, andJunyingYuan 6715SpecificbindingofPCBP1toheavilyoxidizedRNAto inducecelldeath TakashiIshii,HiroshiHayakawa,TatsuhiroIgawa,Takeshi Sekiguchi,andMutsuoSekiguchi 6721 RolesofGag-RNAinteractionsinHIV-1virus assemblydecipheredbysingle-molecule localizationmicroscopy YantaoYang,NaQu,JieTan,MuazN.Rushdi,ChristopherJ. Krueger,andAntonyK.Chen DEVELOPMENTALBIOLOGY E5954 Wnt/  -cateninsignalingregulatesependymalcell developmentandadulthomeostasis LiujingXing,TeniAnbarchian,JonathanM.Tsai,GilesW.Plant, andRoelandNusse 6727 CHD4andtheNuRDcomplexdirectlycontrolcardiac sarcomereformation CaralynnM.Wilczewski,AustinJ.Hepperla,TakashiShimbo, LaurenWasson,ZacharyL.Robbe,IanJ.Davis,PaulA.Wade, andFrankL.Conlon ECOLOGY E5963Metapopulationstabilityinbranchingrivernetworks AkiraTerui,NobuoIshiyama,HirokazuUrabe,SatoruOno, JacquesC.Finlay,andFutoshiNakamura 6733Allometricscalingofestuarine ecosystemmetabolism NicholasJ.Nidzieko 6739Arthropodsinmodernresinsrevealifamber accuratelyrecordedforestarthropodcommunities Mo ´nicaM.Solo ´rzanoKraemer,XavierDelclo `s,MatthewE. Clapham,AntonioArillo,DavidPeris,PeterJa ¨ ger,Frauke Stebner,andEnriquePen ˜ alver SeeCommentaryonpage6525 6745Speciescoexistencethroughsimultaneous fluctuation-dependentmechanisms AndrewD.Letten,ManpreetK.Dhami,Po-JuKe, andTadashiFukami ENVIRONMENTALSCIENCES 6751Widespreadlossofintermediatesoilhorizonsin urbanlandscapes DustinL.Herrmann,LauraA.Schifman,andWilliamD.Shuster 6756 Primaryproductivitybelowtheseaflooratdeep-sea hotsprings JesseMcNichol,HryhoriyStryhanyuk,SeanP.Sylva, Franc ¸oisThomas,NiculinaMusat,JeffreyS.Seewald, andStefanM.Sievert EVOLUTION E5970 Recurrentsymbiontrecruitmentfromfungal parasitesincicadas YuMatsuura,MinoruMoriyama,Piotrukasik,Dan Vanderpool,MasahikoTanahashi,Xian-YingMeng,JohnP. McCutcheon,andTakemaFukatsu 6762Competitionformatesandtheimprovementof nonsexualfitness LiYun,PatrickJ.Chen,KevinE.Kwok,ChristopherS.Angell, HowardD.Rundle,andAneilF.Agrawal 6768Geneticsofalternativesplicingevolutionduring sunflowerdomestication ChrisC.R.Smith,SilasTittes,J.PaulMendieta,Erin Collier-zans,HeatherC.Rowe,LorenH.Rieseberg, andNolanC.Kane GENETICS 6774AncientgenomesfromNorthAfricaevidence prehistoricmigrationstotheMaghrebfrom boththeLevantandEurope RosaFregel,FernandoL.Me ´ndez,YoussefBokbot,Dimas Mart ´ n-Socas,Mar ´ aD.Camalich-Massieu,JonathanSantana, JacobMorales,Mar ´ aC.A ´ vila-Arcos,PeterA.Underhill,Beth Shapiro,GenevieveWojcik,MortenRasmussen,Andre ´E.R. Soares,JoshuaKapp,AlexandraSockell,FranciscoJ. Rodr ´ guez-Santos,AbdeslamMikdad,AiozeTrujillo-Mederos, andCarlosD.Bustamante IMMUNOLOGYANDINFLAMMATION E5980DistincthumancirculatingNKp30 + Fc e RI  + CD8 + Tcellpopulat

5 ionexhibitinghighnatural killer-likeanti
ionexhibitinghighnatural killer-likeantitumorpotential MargaretaP.Correia,AnaStojanovic,KatharinaBauer,Dilafruz Juraeva,Lars-OliverTykocinski,Hanns-MartinLorenz,Benedikt Brors,andAdelheidCerwenka vi u www.pnas.org Contents 6780ChromatinremodelingbytheNuRDcomplex regulatesdevelopmentoffollicularhelper andregulatoryTcells ErxiaShen,QinWang,HardisRabe,WenquanLiu,Harvey Cantor,andJianmeiW.Leavenworth 6786CriticalroleofintegrinCD11cinsplenicdendriticcell captureofmissing-selfCD47cellstoinduce adaptiveimmunity JiaxiWu,HuaizhuWu,JinpingAn,ChristieM.Ballantyne, andJasonG.Cyster 6792MechanismofgasderminDrecognitionby inflammatorycaspasesandtheirinhibitionby agasderminD-derivedpeptideinhibitor JieYang,ZhonghuaLiu,ChuanpingWang,RuiYang, JosephK.Rathkey,OtisW.Pinkard,WuxianShi, YinghuaChen,GeorgeR.Dubyak,DerekW.Abbott, andTsanSamXiao 6798 SUMO2andSUMO3redundantlypreventa noncanonicaltypeIinterferonresponse JohnT.CrowlandDanielB.Stetson MEDICALSCIENCES E5990HypoxictumormicroenvironmentactivatesGLI2via HIF-1
andTGF-  2topromotechemoresistancein colorectalcancer Yen-AnTang,Yu-fengChen,YiBao,SylviaMahara,Siti MaryamJ.M.Yatim,GokceOguz,PuayLengLee,MinFeng, YuCai,ErnYuTan,SauShungFong,Zi-huanYang,PingLan, Xiao-jianWu,andQiangYu E6000Glycosylation-dependentgalectin – receptor interactionspromote Chlamydia trachomatis infection AgustinL.Lujan,DiegoO.Croci,Julia ´nA.GambarteTudela, AntonellaD.Losinno,AlejandroJ.Cagnoni,KarinaV.Marin ˜ o, Mar ´ aT.Damiani,andGabrielA.Rabinovich E6010Cancer-mutationnetworkandthenumberand specificityofdrivermutations JaimeIranzo,In ˜ igoMartincorena,andEugeneV.Koonin E6020AdisorderedacidicdomaininGPIHBP1harboring asulfatedtyrosineregulateslipoproteinlipase KristianK.Kristensen,SørenRoiMidtgaard,SimonMysling, OlegKovrov,LarsBoHansen,NicholasSkar-Gislinge, AnneP.Beigneux,BirtheB.Kragelund,GunillaOlivecrona, StephenG.Young,ThomasJ.D.Jørgensen,LorenG.Fong, andMichaelPloug E6030 YES1 amplificationisamechanismofacquired resistancetoEGFRinhibitorsidentified bytransposonmutagenesisand clinicalgenomics Pang-DianFan,GiuseppeNarzisi,AnithaD.Jayaprakash,Elisa Venturini,NicolasRobine,PeterSmibert,SorenGermer, HelenaA.Yu,EmmetJ.Jordan,PaulK.Paik,YelenaY. Janjigian,JamieE.Chaft,LuWang,AchimA.Jungbluth,Sumit Middha,LeeSpraggon,HuanQiao,ChristineM.Lovly,MarkG. Kris,GregoryJ.Riely,KaterinaPoliti,HaroldVarmus, andMarcLadanyi E6039 AnoncanonicalPPAR  /RXR
-bindingsequence regulatesleptinexpressioninresponseto changesinadiposetissuemass YinxinZhang,OlofStefanDallner,TomoyoshiNakadai,Gulya Fayzikhodjaeva,Yi-HsuehLu,MitchellA.Lazar,RobertG. Roeder,andJeffreyM.Friedman 6804Effectofenvironmentalchangesonvegetableand legumeyieldsandnutritionalquality PaulineF.D.Scheelbeek,FrancesA.Bird,HannaL.Tuomisto, RosemaryGreen,FrancescaB.Harris,EdwardJ.M.Joy,Zaid Chalabi,ElizabethAllen,AndyHaines,andAlanD.Dangour 6810DiverseAR-V7cistromesincastration-resistant prostatecanceraregovernedbyHoxB13 ZhongChen,DayongWu,JenniferM.Thomas-Ahner, ChangxueLu,PeiZhao,QingfuZhang,ConnorGeraghty, PearllyS.Yan,WilliamHankey,BenjaminSunkel,Xiaolong Cheng,EmmanuelS.Antonarakis,Qi-EnWang,ZhihuaLiu, TimH.-M.Huang,VictorX.Jin,StevenK.Clinton,JunLuo, JiaotiHuang,andQianbenWang SeeCommentaryonpage6528 6816Potentlaminin-inspiredantioxidantregenerative dressingaccelerateswoundhealingindiabetes YunxiaoZhu,ZdravkaCankova,MartaIwanaszko,Sheridan Lichtor,MilanMrksich,andGuillermoA.Ameer MICROBIOLOGY E6048 Directactivationofaphospholipasebycyclic GMP-AMPinElTor Vibriocholerae GeoffreyB.Severin,MiriamS.Ramliden,LisaA.Hawver,Kun Wang,MacyE.Pell,Ann-KatrinKieninger,AtulKhataokar, BrendanJ.O’Hara,LaraV.Behrmann,MatthewB. Neiditch,ChristophBenning,ChristopherM.Waters, andWai-LeungNg 6822 Differentiatedhumanairwayorganoidstoassess infectivityofemerginginfluenzavirus JieZhou,CunLi,NormanS

6 achs,ManChunChiu,BoscoHo-Yin Wong,HinChu
achs,ManChunChiu,BoscoHo-Yin Wong,HinChu,VincentKwok-ManPoon,DongWang,Xiaoyu Zhao,LeiWen,WenjunSong,ShuofengYuan,Kenneth Kak-YuenWong,JasperFuk-WooChan,KelvinKai-WangTo, HonglinChen,HansClevers,andKwok-YungYuen 6828 Distributionandfunctionalanalysisofthe phosphopantetheinyltransferasesuperfamily in Actinomycetales microorganisms JeongHoKim,MamoruKomatsu,KazuoShin-ya,Satoshi Omura,andHaruoIkeda 6834Cell-basedscreenfordiscoveringlipopolysaccharide biogenesisinhibitors GeZhang,VadimBaidin,KaranbirS.Pahil,EileenMoison, DavidTomasek,NityaS.Ramadoss,ArnabK.Chatterjee, CaseW.McNamara,TravisS.Young,PeterG.Schultz, TimothyC.Meredith,andDanielKahne SeeCommentaryonpage6530 6840 Bacterialironacquisitionmediatedbyouter membranetranslocationandcleavageof ahostprotein KhedidjaMosbahi,MartaWojnowska,AmayaAlbalat, andDanielWalker 6846 Staphylococcusaureus targetsthepurinesalvage pathwaytokillphagocytes VolkerWinstel,DominiqueMissiakas,andOlafSchneewind NEUROSCIENCE E6056Neuralnetworkretuningandneuralpredictorsof learningsuccessassociatedwithcellotraining IndianaWollman,VirginiaPenhune,MelanieSegado,Thibaut Carpentier,andRobertJ.Zatorre E6065Caspase-1inhibitionpreventsglialinflammasome activationandpyroptosisinmodelsof multiplesclerosis BrienneA.McKenzie,ManmeetK.Mamik,LeinaB.Saito, RoobinaBoghozian,MariaChiaraMonaco,EugeneO.Major, Jian-QiangLu,WilliamG.Branton,andChristopherPower 6852Evidenceformutualallocationofsocialattention throughinteractivesignalinginamormyrid weaklyelectricfish MartinWorm,TimLandgraf,JuliaPrume,HaiNguyen,Frank Kirschbaum,andGerhardvonderEmde Contents PNAS u June26,2018 u vol.115 u no.26 u vii 6858Originofslowspontaneousresting-stateneuronal fluctuationsinbrainnetworks GiriP.Krishnan,OscarC.Gonza ´lez,andMaximBazhenov PLANTBIOLOGY E6075 LOWPHOTOSYNTHETICEFFICIENCY1isrequired forlight-regulatedphotosystemIIbiogenesis in Arabidopsis HongleiJin,MeiFu,ZhikunDuan,SujuanDuan,MengshuLi, XiaoxiaoDong,BingLiu,DongruFeng,JinfaWang,Lianwei Peng,andHong-BinWang E6085 Astressrecoverysignalingnetworkforenhanced floodingtolerancein Arabidopsisthaliana ElaineYeung,HansvanVeen,DivyaVashisht,AnaLuizaSobral Paiva,MaureenHummel,TomRankenberg,BiankaSteffens, AnjaSteffen-Heins,MargretSauter,MicheldeVries, RobertC.Schuurink,Je ´re ´mieBazin,JuliaBailey-Serres, LaurentiusA.C.J.Voesenek,andRashmiSasidharan 6864Auxinmethylationisrequiredfordifferentialgrowth in Arabidopsis MohamadAbbas,JorgeHerna ´ndez-Garc ´ a,Stephan Pollmann,SophiaL.Samodelov,MartinaKolb,Ji
r ´ Friml, UlrichZ.Hammes,MatiasD.Zurbriggen,MiguelA.Bla ´zquez, andDavidAlabad ´ SYSTEMSBIOLOGY 6572StochasticTuringpatternsinasynthetic bacterialpopulation DavidKarig,K.MichaelMartini,TingLu,NicholasA.DeLateur, NigelGoldenfeld,andRonWeiss CORRECTION(ONLINEONLY) ECOLOGY,SUSTAINABILITYSCIENCE E6095Patternsofplantcarbon,nitrogen,andphosphorus concentrationinrelationtoproductivityinChina ’ s terrestrialecosystems ZhiyaoTang,WentingXu,GuoyiZhou,YongfeiBai,JiaxiangLi, XuliTang,DimaChen,QingLiu,WenhongMa,Gaoming Xiong,HonglinHe,NianpengHe,YanpeiGuo,QiangGuo, JianglingZhu,WenxuanHan,HuifengHu,JingyunFang, andZongqiangXie SICORRECTIONS(ONLINEONLY) EARTH,ATMOSPHERIC,ANDPLANETARYSCIENCES E6097Directmeasurementsofmeltwaterrunoffonthe Greenlandicesheetsurface LaurenceC.Smith,KangYang,LincolnHPitcher,BrandonT. Overstreet,VenaW.Chu,A  saK.Rennermalm,JonathanC. Ryan,MatthewG.Cooper,ColinJ.Gleason,MarcoTedesco, JeyavinothJeyaratnam,DirkvanAs,MichielR.vanden Broeke,WillemJanvandeBerg,BriceNoe ¨ l,PeterL.Langen, RichardI.Cullather,BinZhao,MichaelJ.Willis,AlunHubbard, JasonE.Box,BrittanyA.Jenner,andAlbertoE.Behar BIOPHYSICSANDCOMPUTATIONALBIOLOGY E6098Howelectrostaticnetworksmodulatespecificityand stabilityofcollagen HongningZheng,ChengLu,JunLan,ShilongFan,Vikas Nanda,andFeiXu viii u www.pnas.org Contents