LECTURE 07 LEARNING OBJECTIVES The student should be able to Describe the term autoimmune indicate if it is either Define the term autoantibodies Determine if the autoantibodies eit ID: 937006
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LECTURE : 07 AUTOIMMUNITY & AUTOIMMUNE DISEASE LEARNING OBJECTIVES : The stud
ent should be able to: Describe the term "autoimmune", indicate if it is either Define the te
rm "autoantibodies". Determine if the autoantibodies either pathogenic or not. Determine if aut
oimmune diseases are organ specific or systemic. Enumerate some examples of orsystemic. Determi
ne is it possible that an individual may have more and systemic autoimmune disease Explain the in
volvement of genetic factors in autoimmunity. Determine if the formed iwith organ-specific or sys
temic autoimmunity. Determine if there are any autoreactive T and B lymphocytes normally present
in normal people. Enumerate some autoimmune Dermatomyositis - Hashimoto's thyroiditis - Diab
etes Enumerate some autoimmune Encephalomyelitides - Guillain-Barre syndrome. Explain the
mechanism of lymphocytes to generate autoimmune responses such as: - Viral infections. - Drugs.
Cross reactivity (Molecular mimicry). - Hormonal factor. . In the normal thyroid space (cs) int
o which they secrete thyroglobulin, which is broken down on demand to provide thyroid hormones (cap
=capillaries containing and blood cell). In the Hshimoto gland (2), the normal architectrure is vir
tually destrconsist essentially of lyphocytes, macrophages and plasma cells. A secondary lymphoid f
ollicle (sf), with a germinal centre (gc) and a mantle of small lymphoctes (m), and small Hea
lthy unfixed human thyroid sections were treated with patients' serum, and then with fluoresceinate
d rabbit anti-human lg. Some acinar epithelial cells of the follicles are stained by antibodies fro
m a patient with Hashimoto's disease, which react with the cells' cytoplasm but not the nuclei (1).
In contrast, serum from a patient with SLE (2) contains cytoplasm unstained (2). Autoimmun
e diseases may be claspecific depending on whether the response is primarily against antigens local