studies are to further this entity proposed as an animal model for the - PDF document

studies are to further this entity proposed as an animal model for the study anterior corneal dystrophies of Reis-Bucklers’ J Ophthamol72:549, 1971 A Textbook of Histology, 10th ed., Saunders, Philadelphia, Recurrent erosion dystrophy of the corneal epithelium. Ophthalmol SOC Kuwabara T: Ocular tal hypercholesterolemia. 19, 1959 Barnett KC: lipoides corneae in the Alsation. J Small Anim 7 Dark A J: dystrophy, ultrastructure and photomicroscopy. Corneal dystrophy in the 5th Ann Scientific Pgm, Dallas, 1974 Corneal dystrophy in the Am Coll 241. 15th Ann entific Pgm, Atlanta, 1984 10 Ekins MB, Squoutas lipid stromal opacities b

eagles: VI. stromal cholesterol and phospholipid. Oval lipid corneal Natural history tear function. Recurrent cor- Int Ophthalmol 13 Gwin ocular lipidosis cottontail rabbit all-milk diet. Corneal lipoidosis a domestic short-haired cat-a disease distinct from in the cat. J Am Vet 16 Hogan Histology of ders, Philadelphia, in the lesterol feeding. Am J Ophthalmol58:8 18 Kenyon Invest Ophthalmol 19 Khodadoust of regenerating corneal epithelium. J Ophthal- Ciccarelli EC: corneal dystro- pathological study. Arch Langweiler M, a litter cats. J the neonatal WL, Roth AM: Crystalline corneal opacities Siberian husky. J Med Assoc sions in c

ats with GM,-gangliosidosis volvement. J Small Anim Pract Dodd DC: Two corneal epithelial A clinicopathological study. posterior ectasia dogs. Am 50:45 1, AT, Harris Occurrence of corneal opacities rats after acute 1 -a-acetylmethadol. Toxicol Appl Oval corneal opacities chemical demonstration stromal lipids without perlipidemia. Invest Ophthalmol Vis Sci 21:95, of exper- imental hyperlipoproteinemia in the eye. Exp Morrin LA: Oval lipid cor- neal opacities 32 Stock EL, Mendelsohn Lipid keratopathy 103:726, 1985 33 Tremblay M, Dube corneal dystrophy: features. Can J Ophthalmol terior cornea. Arch Oval corneal Anim Hosp Assoc 13:2

04, Kawaji H: a model corneal dystrophy. ed. Sil- York, 1979 Request reprints from Dr. Cecil P. Moore, Department of Surgical Sciences, Medicine, 20 15 Linden of Wisconsin-Madison, and intensely abnormal epithelial relative acellularity; features include the epithelial basement mem- subepithelial stroma. Corneal opacities this inbred strain ican Dutch rabbits appear true corneal Corneal dystrophies spontaneously, are non-inflammatory, the central cornea, are symmetrically. They with systemic primarily involve a may become second- Corneal opacities in the central or paracentral cornea is involved. bilateral but the animals are fr

ee systemic disease. epithelial basement membrane is consistently ab- stroma also Clinicians have concerned with the epithelial-basement membrane adhesions the corneal Poor adhe- the epithelial ment membrane may result in recurrent epithelial the corneal surface which disabling in human human pa- tients, the anterior corneal dystrophies a primary recurrent corneal epithelial The importance normal basement membrane the maintenance tight adhesions be- the epithelial basal the anterior cover denuded ment membrane. Tight adhesions formed basement membrane cornea.Ig When basement membrane weeks were required for corneal epithelium-bas

ement complex with resulting anchoring filaments corneal epithelium the formation corneal epithelial basement membrane merit further the present study corneal epi- thelial basement membrane have abnormal may be for investigating the sequential contributions adjacent stromal keratocytes epithelial basement membrane formation. Ultra- structurally corneal epithelial basement membrane a reticulum with ground substance other basement mem- is a product the epithelial that the with their associated tissue fibroblasts.2 on present the term anterior corneal American Dutch belted rabbits is as the most appropriate designation for order. Re

searchers carefully screen all American Dutch belted rabbits prior anterior cornea of left eye thickened basement abnormal basement membrane anterior stroma anterior cornea of left Note markedly thickened abnormal basement membrane area normally occupied by basal epithelial Jones HE. Histologic section anterior cornea of left female rabbit contrast illumination. Corneal epithelial thickness is diminished layers, basal cell small and stain basement membrane is thickened corneal stroma disorganized. Within anterior stroma note relative acellarity and irregular arrangement by guest on February 19, 2011vet.sagepub.comDownloaded fr