Dr Nick Salamie PharmD RPh Autoimmune Disorders Symptoms Traditional Treatments NSAIDs Aleve Advil Immunosuppressant Drugs Corticosteroids Janus kinase inhibitors Calcineurin inhibitors ID: 774724
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Cannabis & Autoimmune Disorders
Dr. Nick Salamie PharmD, RPh
Slide2Autoimmune Disorders
Slide3Symptoms
Slide4Traditional Treatments
NSAIDsAleveAdvilImmunosuppressant DrugsCorticosteroidsJanus kinase inhibitorsCalcineurin inhibitorsmTOR inhibitorsIMDH inhibitorsBiologicsMonoclonal antibodies
Slide5Slide6Endocannabinoid System
Complex Regulatory SystemRegulates Immune ResponseCB1 and CB2 ReceptorsImmune Cells Express BothEndocannabinoid and PhytocannabinoidsImmunosuppressive PropertiesCell deathInhibition of Cell GrowthInhibition of signaling and regulatory proteinsInhibition of white blood cell attractionTHC modulates T-helper cells
Slide7Multiple Sclerosis
Cannabis useful for symptom reliefSpasticityPainSleepMay reduce progression in early MSCannabis StrategiesDay: CBD/THCNight: THC Inhalation, Oral and SublingualDosing based on patients cannabis experienceAdvanced Consideration: Beta-Caryophyllene
Slide8Rheumatoid Arthritis
Symptom Relief
PainFatigueMoodInflammationTHCCBDTHCaCBCBeta-Caryophyllene
This Photo
by Unknown Author is licensed under
CC BY-NC-ND
Slide9First PDI Visit
GoalsIncrease Quality of LifeDrug InteractionsAssess Patients Cannabis ExperienceNo or little cannabis experienceIntermediate cannabis experienceAdvanced Cannabis ExperienceTapering Strategy if NecessaryProduct selection and initial strategyMinimum Effective DoseFollow Up
Slide10Dosage Forms
InhalationCombustionVaporizationIngestibleEdiblesOils (RSO)Tablets/CapsulesSublingual/Buccal/OromucosalTopicalTransdermal
Slide11Cannabis Oils/RSOs
Best medical dosage form
Whole Plant/Full Spectrum Extract/Herbal ShotgunVarying Cannabinoid ProfilesDifferent CBD:THC ratiosAcidic Cannabinoids: THCa, CBDa, CBGa“Varin” Cannabinoids: THCV, CBDVLess abundant Cannabinoids: CBN, CBG, CBCTerpenes CapturedBeta-Caryophyllene
Slide12Getting Your Cannabis Card
Formal Diagnosis of 1 of the 41 qualifying conditions
Completion of Physician Written Certification Form by a Licensed PhysicianFingerprint/Background CheckCompletion of Online Registration and and PaymentProvisional Registration
Slide13Resources
“Autoimmune Diseases: Types, Symptoms, Causes, Diagnosis & More.”
Healthline
, Healthline Media, www.healthline.com/health/autoimmune-disorders#common-autoimmune-diseases.
Backes, Michael, et al.
Cannabis Pharmacy: the Practical Guide to Medical Marijuana
. Black Dog & Leventhal Publishers, 2017.
“Health: Autoimmune Disorders and Cannabis.” Performance by Michele Ross,
Green Flower Media
, www.green-flower.com/episodes/504/autoimmune-disorders-and-cannabis.
“Immunosuppressant Drugs: A Complete Overview.”
Healthline
, Healthline Media, www.healthline.com/health/immunosuppressant-drugs.
Russo, Ethan B., and Jahan
Marcu
. “Cannabis Pharmacology: The Usual Suspects and a Few Promising Leads.”
Cannabinoid Pharmacology Advances in Pharmacology
, 2017, pp. 67–134., doi:10.1016/bs.apha.2017.03.004.
Slide14Questions