Dr Zahra Rashid Khan Assistant Professor Hematology Department of Pathology EPIDEMIOLOGY INTRODUCTION THE MALARIAL PARASITE Plasmodium vivax benign tertian Plasmodium ovale benign tertian ID: 489589
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MALARIAL PARASITE
Dr Zahra Rashid Khan,Assistant Professor, HematologyDepartment of PathologySlide2Slide3
EPIDEMIOLOGYSlide4
INTRODUCTIONSlide5Slide6
THE MALARIAL PARASITE
Plasmodium vivax (benign tertian)
Plasmodium
ovale
(benign tertian)
Plasmodium
falciparum
(malignant tertian)
Plasmodium
malariae
(benign quartan)Slide7
MALARIASlide8
TRANSMISSION
Mosquito bite Transplacental
Transfusion
IV drug abuseSlide9
INCUBATIONSlide10
CLINICAL FEATURESSlide11
“INTERMITTENT FEVER”Slide12Slide13
P.FALCIPARUM MALARIA
Occlusion of capillaries with aggregates of parasitized RBCCerebral malaria
Acute renal failure
Extensive
hemolysis
AnemiaSlide14
MORPHOLOGYSlide15Slide16
PLASMODIUM VIVAXSlide17Slide18
PLASMODIUM VIVAXSlide19Slide20
PLASMODIUM FALCIPARUMSlide21
PLASMODIUM FALCIPARUMSlide22
DIAGNOSISSlide23
MICROSCOPY
Thick blood filmThin Blood filmSlide24Slide25
MOLECULAR METHODS
Polymerase Chain Reaction (PCR)Highly specific and sensitive (1-5 parasite/mL
of blood)) Slide26
RAPID TESTING(ICT)Slide27
SEROLOGICAL METHODS
Not useful for diagnosis of acute infectionEpidemiological toolSlide28
MANAGEMENTSlide29
PREVENTIVE MEASURES
Mosquito netsWindow screensProtective clothingInsect repellentsDrainage of stagnant water Slide30
PREVENTIVE MEASURES
Chemoprophylaxis for travelers(chloroquine /
mefloquine
or
doxycycline
)Slide31
TREATMENT OPTIONS
Sensitive casesChloroquine
Primaquine
Resistant cases
Quinine &
Doxycycline
Quinine &
Fansidar
Artemisinins
Slide32
RESISTANCESlide33
PREVENTION BETTER THAN CURE!Slide34