Dr SALINI CHANDRAN Deptof Forensic Medicine amp Toxicology RED PHOSPHORUS YELLOWWHITE PHOSPHOROUS Fertilizers Insecticides Rodenticides Incendiary bombs Smoke screens Fireworks DIFFERENT FORMS OF PHOSPHOROUS ID: 1009584
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1. PHOSPHORUS Inorganic Irritant poisonDr. SALINI CHANDRANDept.of Forensic Medicine & Toxicology
2. RED PHOSPHORUS YELLOW/WHITE PHOSPHOROUSFertilizersInsecticidesRodenticidesIncendiary bombsSmoke screensFireworksDIFFERENT FORMS OF PHOSPHOROUS
3.
4. ACTIONProtoplasmic poisonAffects cellular oxidation
5. Local effects Local damage to skin,GIT ,mucous membrane ,respiratory tract Oxidative damage Thermal damageACTION
6. Systemic effects General protoplasmic poison Impair ribosomal function and protein synthesis Cause free radicle injury Impair lipoprotein synthesis Fatty degeneration ACTION
7. Depress myocardial protein synthesis Impair contractility and cause vasodilation Common cause of early death CARDIOVASCULAR SYSTEM
8. Neuronal toxicity Cerebral hypo perfusion Hypoglycemia CENTRAL NERVOUS SYSTEM
9. ACUTECHRONICFULMINATINGTYPES OF POISONING
10. More than 1 gmDeath within 12 hrsShock and Cardiovascular collapse Those who surviveRestless delirious & maniacalSevere nausea, vomiting and retchingFULMINATING
11. STAGE 1 Last for several hours Burning tastepain in throat and abdomenNausea ,vomiting ,diarrhea, abdominal pain Mucosal burning Breath ,stool, vomitus have garlic odorPhosphorescent Tachycardia ,hypotension ,shock and coma may develop Burns (2nd and 3rd degree) - Skin ContactACUTE POISONING
12. STAGE 2 Quiescent stage Last for 1-3 days Some gastrointestinal abnormalities may present ACUTE POISONING
13. STAGE 3 • Few days after ingestion • End organ damage • Nausea ,vomiting, abdominal pain , convulsions • Liver injury Hges intoskin mucous membrane,and visceraACUTE POISONING
14. STAGE 3 •Renal DamageOliguria , Haematuria, casts, albuminuriaDeath from shock , hepatic failure CNS DamageACUTE POISONING
15. FATAL DOSE- 60 to 120mg Fatal Period - 2 to 8 daysFATAL DOSE & PERIOD
16. ULTRAVIOLET LIGHT SERUM PHOSPHORUS LEVELS SERUM ELECTROLYTES & CALCIUM LEVELSDIAGNOSTIC TESTS
17. Gastric lavage with potassium permanganate (1:5000)Activated CharcoalStomach wash with CuSO4 0.2gm12 gm of CuSO4every 5 mins till vomiting occursVit K Whole bowel irrigation Exchange transfusion Peritoneal or haemodialysisTREATMENT
18. GIT- IrritationLuminous material in stomachJaundiceGarlicky odourMucous membrane of stomach- yellowish or greyish whiteSoftened ,thickened, lnflamed, corroded in patchesPM Appearance
19. Liver- swollen yellow, soft,easily rupturedKidneys- Large, greasy, yellow with hgic spotsMucous membrane of stomach- yellowish or greyish whiteHeart- Pale and flabby with fatty degenerationPM Appearance
20. PHOSSY JAWSYSTEMICCHRONIC POISONING
21. Accidental in chidrenOccasionally for homicideSometimed for abortionArsonML IMPORTANCE