Research Fund Divry Innogenetics Belgium the Netherland Scientific - PDF document

Research Fund Divry, Innogenetics, Belgium; the Netherland Scientific Research the Eurodem Action of the Nestor Stimulation Program of Research into the Dutch Ministry of Ministry of Educa- the Netherlands, Alzheimer Association, research associate of the 1. Mahley cholesterol transport protein with expanding role cell biology. Science 1988;240:622-640 Choroid Choroid Patient Age Disease Deposits Focal vasculitis ”Interval herween and death those diagnosed idiopathic thromhocytopenic levels of generally correlate correlate )These ICs contain specific immunoglobulin isotypes, and antigens human immunodeficiency fectious agents agents Deposition of ICs into tissue may damage systemic organs such as but the blood-brain barrier, macromolecules, including from entering. choroid plexus, however, deposition since its capillaries have “gap” junc- In ad- dition, choroid plexus receptors for for 51 may increase its vulnerability we examined choroid plexus deposition. In patients with nervous syste

m plexus frequently frequently (personal observations, 1994). A preliminary re- port of this study was published previously [73. Materials and Methods Formalin-fixed choroid plexus specimens frozen sections was unavailable. Paraffin-embedded sections with hemaroxylin incubation with monoclonal anti- dilution; Genetics Systems, Seat- Following incuba- tion with primary antisera, sections the choroid and azan sequentially incubated with biotinylated secondary and hydrogen 3,3’-diaminobenzidine. A previously diagnosed identification of (for anti-IgG and in each slide Saline solution primary antibody a negative was blindly for the hypertrophy, and cell proliferation-each IC deposition Fifteen patients were men four were women; their tion included homosexuality (in abuse (in and promiscu- and were unknown age, sex, risk factors, duration of AIDS, AIDS-related infections presence of deposits in patients had infectious agents the choroid microscopic exami- focal infiltrates plasma cells perivascular area

s. vesicular nuclei, and mesenchymal frequently with for adequate and thus significance of basement membrane of choroid plexus epithelium. patients, homoge- acidophilic, PAS-positive were seen azan positive (Fig plexus in patients (Patients patients although subepithelial regions. ICs in patients with those without develop from antigen-antibody complex of comple- and thus are tious, neoplastic, which has associated with systemic vasculitis and glomerulone- Tissues that highly vascularized junctions such kidney and choroid plexus at increased choroid plexus lupus ery- thematosus, hepatosplenic hepatosplenic 1 1 ] but not with diseases a known complication In ad- related IC-mediated renal disease nerve and and have been described. The pres- ent demonstration of frequent IC plexus of additional evidence associated with endothelial hypertrophy mesenchymal proliferation were deposited from as local deposition of normal brains and choroid and choroid plexus inflammation. choroid plexus could damage and alter

and pleocytosis, plexus ab- normalities could position could choroid plexus vulnerable choroid plexus renders the the This study was supporred by grants from the Conselho of Health Brenda Roberts, plexes in acquired immunodeficiency disease manifestation, and immunologic virus infection. 144: 1 antigen, anti- and HIV-containing infected patients. 4. Braarhen in human plexus. Clin lmmunopathol 1979; Roxburgh VA, Binding sites choroid plexus. Arthritis Rheum Falangola MF, plexus infection in cerebral Neurology 1993;43:2035- 7. Falangola choroid plexus of patients. Ann Chernack WB, nephritis. Arch Intern Med 1972; Pittella JE, Bambirra Histopathological and immunofluo- rescence study of choroid plexus in hepatosplenic Med 1991;115:220- 12. Kimmel Ferreira-Centeno A, human immu- nodeficiency virus Med 1992;327:702-706 necrorizing arreritis: a spinal fluid findings in of human immunodefi- virus infection. 15. Peress Gruenewald R, of experimental central system listeriosis in rats immunohistopathological stu