Research NHMRC CTC 30th Anniversary S ymposium 1 March 2019 The future of clinical trial funding Professor Anne Kelso AO Chief Executive Officer Clinical trials funding in NHMRCs new grant program ID: 1043789
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1. 30/30 Horizons in Healthcare ResearchNHMRC CTC 30th Anniversary Symposium 1 March 2019The future of clinical trial fundingProfessor Anne Kelso AO Chief Executive Officer
2. Clinical trials funding in NHMRC’s new grant program
3. NHMRC’s new grant program – four streamsInvestigator GrantsSynergy GrantsIdeas GrantsStrategic and leveraging grantsSupport the research program of outstanding investigators at all career stagesSupport outstanding multidisciplinary teams to work together to answer major questions that cannot be answered by a single investigatorSupport innovative research projects addressing a specific questionResearch that responds to national priorities:CREsPartnershipsDevelopment GrantsTargeted Calls International schemesClinical trials and cohort studiesSalary + research support packageResearch costs ($5 million)Research costsResearch costsOne per investigator*One per investigatorTwo per investigator*No caps* Researchers may hold one Investigator Grant or up to two Ideas Grants
4. NHMRC’s new grant program – redividing the pieOld grant programNew grant programClinical Trials & Cohort Studies~$70 million p.a.
5. To support research that addresses identified national needsSTRATEGIC AND LEVERAGING GRANTSIncludes new scheme – Clinical Trials and Cohort StudiesObjective: support high-quality clinical trials and cohort studies that address important gaps in knowledge, leading to relevant and implementable findings for the benefit of human healthOpen to research proposals for clinical trials and/or cohort studies of any size, including:applications for new clinical trials and/or cohort studiesproposals to answer research questions using findings from existing trials or cohort studies.Criteria:Significance (40%)Research Quality (40%)Team Quality and Capability (20%)Greater visibility and no capsFocus on rationale (systematic review)Design: SPIRIT and STROBE checklistsMilestone reporting
6. To support research that addresses identified national needsSTRATEGIC AND LEVERAGING GRANTSIncludes new scheme – Clinical Trials and Cohort StudiesObjective: support high-quality clinical trials and cohort studies that address important gaps in knowledge, leading to relevant and implementable findings for the benefit of human healthOpen to research proposals for clinical trials and/or cohort studies of any size, including:applications for new clinical trials and/or cohort studiesproposals to answer research questions using findings from existing trials or cohort studies.Criteria:Significance (40%)Research Quality (40%)Team Quality and Capability (20%)Applications open6 March 2018Minimum data due10 April 2019Applications close8 May 2019Peer reviewAug/Sep 2019
7. Timing of opening/closing of funding schemes in 2019SchemeOctNovDecJanFebMarAprMayJunJulAugSepOctNovDecCREsDevelopmentInvestigatorSynergyIdeasClinical trialsPostgraduatePartnershipTCRsInternationalDementiaMRFF
8. Medical Research Future Fund
9. NHMRC and MRFF budgets – to be updated 2 April 2019Source: 2018-19 Portfolio Budget Statements
10. The future of clinical trial funding - practicalitiesNHMRC will continue to support investigator-initiated clinical trials across all disease areas.Scheme guidelines and peer review processes will need to keep up with new approaches to clinical trial design.Scheme budgets will be reviewed annually as usual.Scheme may evolve over time – please give us feedback.MRFF is focussed on government priorities, which may change over time.NHMRC will continue to deliver funding schemes (including clinical trial schemes) for MRFF at the request of Department of Health.There are opportunities for future streamlining of NHMRC and MRFF clinical trial schemes.Watch GrantConnect!Read the Guidelines!
11. The future of clinical trial funding – in 30 years?Funders will expect:value: clear evidence of need, potential impact and pathway to uptakeend-user engagement: participant, policy maker, healthcare providerinternational linkages for recruitment and data sharingtrial registration and open data sharingtrials embedded in routine clinical practiceFunders will need to provide:data inter-operability (with ethics applications, registries etc)flexibility to evaluate and fund new, more efficient trial designsmore frequent/continuous funding cyclessimple reporting mechanisms
12. Thank you