PPT-Chapter 17 – from gene to protein

1 The information content of genes is in the form of specific sequences of nucleotides along the DNA strands The DNA of an organism leads to specific traits by dictating the synthesis of proteins and of RNA molecules involved in protein synthesis . Interactions. June 18, 2015. Why PPI?. Protein-protein interactions determine outcome of most cellular processes. Proteins which are close homologues often interact in the same way. Protein-protein interactions place evolutionary constraints on protein sequence and structural divergence. k. -partite graphs. Sarah . Gester. , . Ermir. . Qeli. , Christian H. Ahrens, and Peter . Buhlmann. Problem Description. Given peptides and scores/probabilities, infer the set of proteins present in the sample.. Sergio G Peisajovich, Liat Rockah & Dan S Tawfik. Introduction. Protein Folds. Protein folding.  is the process by which a protein structure assumes its functional shape or conformation. . It is the physical process by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil. Alexey Onufriev, . Virginia Tech. www.cs.vt.edu/~onufriev. Proteins play key roles in a living system. Three (out of many many) examples of protein functions. Catalysis:. Almost all chemical reactions in a living cell are catalyzed by protein enzymes.. Tonya C. Bates. Erin Dolan. Meredith S. Norris. John Rose. Tarren Shaw. Suann Yang. Ron Zimmerman. Facilitators: Kelly Hogan and Jennifer Warner. Gene Expression. Topic: Genetic Regulation. Context: Large lecture section of introductory biology students . Interactions. June 6, 2017. Why PPI?. Protein-protein interactions determine outcome of most cellular processes. Proteins which are close homologues often interact in the same way. Protein-protein interactions place evolutionary constraints on protein sequence and structural divergence. The DNA inherited by organisms leads to specific traits by dictating synthesis of proteins . The process by which DNA directs protein synthesis is called . Gene Expression. Transcription. Translation. Dynamic modeling. Stefan Legewie & Sofya Lipnitskaya. Institute of Molecular Biology, Mainz. What is dynamic model of a biological system?. (g) Comparison/fitting to data. . Iterative cycle of model and experiment . TUMOR SUPRESSOR PROTEINS. ATP. ENZYMES THAT CONTROL CELLULAR RESPIRATION. ADAPTIVE GENE PRODUCTS ARE ONLY REQUIRED UNDER CERTAIN CONDITIONS. GENES FOR PROTEIN DIGESTION ARE TURNED OFF WHEN THERE IS NO PROTEIN AVAILABLE. . LapA. in LPS Assembly. Aarthi Prakash. December 1, 2017. Lipopolysaccharide. Outer membrane of E. Coli. LPS . 6 Fatty Acyl Side Chains with many sugars attached. LPS bind together. Provides gel like barrier. Controlling gene expression is often accomplished by controlling transcription initiation.. Regulatory proteins . bind to DNA to either block or stimulate transcription, depending on how they interact with RNA polymerase.. Junying Yuan,tS Shai Shaham,t Stephane Ledoux,S§ Hilary M. Ellis,tll and H. Robert Horvitzt *Program of Neurosciences Harvard Medical School Boston, Massachusetts 02115 iHoward Hughes Medical Institu Prediction . Wang Yang. 2014.1.3. Outline. Molecular. . Co-evolution . phenomenon. A. pplications . of Co-evolution . in . protein structure prediction and PPI prediction.. Co-evolution measurement: . ANALYSIS. PROTEIN . DATABASES. PROTEIN . SEQUENCE. MOTIF/DOMAIN. FOLDINDING. PROPERTIES. TOOLS. http://tw.expasy.org/. http://www.ebi.ac.uk/Tools/pfa/iprscan/. http://www.ncbi.nlm.nih.gov/Structure/cdd/wrpsb.cgi.