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Monoclonal Antibodies and Immunogenicity: Relevance to Clinical Practice? Monoclonal Antibodies and Immunogenicity: Relevance to Clinical Practice?

Monoclonal Antibodies and Immunogenicity: Relevance to Clinical Practice? - PowerPoint Presentation

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Uploaded On 2018-03-13

Monoclonal Antibodies and Immunogenicity: Relevance to Clinical Practice? - PPT Presentation

Program Introduction Technologies Used to Produce Therapeutic mAbs Molecular Structures of Biologic Drugs Used to Treat Psoriasis Biologics Consequences of ADAs Consequences of ADAs Biologics Types of ADAs ID: 649777

antibodies adas immunogenicity mabs adas antibodies mabs immunogenicity relevance consequences biologics

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Presentation Transcript

Slide1

Monoclonal Antibodies and Immunogenicity: Relevance to Clinical Practice?Slide2

Program Introduction Slide3

Technologies Used to Produce Therapeutic mAbsSlide4

Molecular Structures of Biologic Drugs Used to Treat PsoriasisSlide5

Biologics: Consequences of ADAsSlide6

Consequences of

ADAsSlide7

Biologics: Types of ADAsSlide8

Relationship of Developing ADAs to Type of mAbSlide9

Immunogenicity of IL-17a and IL-12/23 Antibodies Are Low vs Other mAbsSlide10

Ixekizumab TE-ADAs Reported in the Phase 3 UNCOVER TrialsSlide11

Relevance of ADAs for Treatment Strategies With Human or Chimeric AntibodiesSlide12

Concluding RemarksSlide13

Abbreviations