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Advances in Gastrointestinal Cancers Advances in Gastrointestinal Cancers

Advances in Gastrointestinal Cancers - PowerPoint Presentation

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Uploaded On 2019-01-31

Advances in Gastrointestinal Cancers - PPT Presentation

This program will include a discussion of data that were presented in abstract form These data should be considered preliminary until published in a peerreviewed journal Immunotherapy in Gastrointestinal ID: 749206

gastric cancer immunotherapy monotherapy cancer gastric monotherapy immunotherapy junction hcc inhibitors checkpoint dual pancreatic cont blockade pembrolizumab inhibition ongoing

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Presentation Transcript

Slide1

Advances in Gastrointestinal CancersSlide2

This program will include a discussion of data that were presented in abstract form.

These data should be considered preliminary until published in a

peer-reviewed journal.Slide3

Immunotherapy in Gastrointestinal MalignanciesSlide4

dMMR and PD-1 BlockadeSlide5

dMMR and PD-1 Blockade (cont)Slide6

dMMR and PD-1 Blockade (cont)Slide7

Immunotherapy in Hepatocellular CarcinomaSlide8

Nivolumab Monotherapy in HCCCheckMate-040Slide9

CheckMate-040Subset AnalysisSlide10

Pembrolizumab Monotherapy in HCCKEYNOTE-224Slide11

Durvalumab Monotherapy in HCCSlide12

Dual Checkpoint Inhibitor Therapy in HCCSlide13

Combined VEGF Inhibition and PD-1 Inhibition in HCCSlide14

Ongoing Trials and Future Directions Slide15

Immunotherapy in Gastroesophageal CancerSlide16

Pembrolizumab Monotherapy in Gastric/Gastroesophageal CancerSlide17

Nivolumab Monotherapy in Gastric and GE Junction CancerSlide18

Avelumab Monotherapy in Advanced Gastric or GE Junction CancerSlide19

Pembrolizumab Monotherapy in Gastric and GE Junction CancerSlide20

Dual Checkpoint Inhibitors in Gastric and GE

Junction Cancers: Nivolumab + IpilimumabSlide21

Dual Checkpoint Inhibitors in Gastric

and GE Junction Cancers: Durvalumab + TremelimumabSlide22

Combination VEGFR-2 and PD-1 Inhibition in the Second Line Management of Gastric or GE Junction Adenocarcinoma Slide23

Ongoing Trials and Future DirectionsSlide24

Immunotherapy in Pancreatic AdenocarcinomaSlide25

Immunotherapy in Pancreatic CancerSlide26

Dual Checkpoint Inhibitors in Pancreatic CancerSlide27

Chemotherapy in Combination With Checkpoint InhibitorsSlide28

Other Immunomodulating AgentsIDO-1 InhibitorsSlide29

Other Immunomodulating Agents: CSF1R BlockadeSlide30

Pancreatic ImmunotherapyOngoing trialsSlide31

Concluding RemarksSlide32