IntroductionOverview IntroductionOverview cont Importance of Prophylaxis and Limitations on Its Application in Hemophilia B Key Unmet Need in Hemophilia B Reducing Patient Burden of Disease ID: 633741
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Prolonging the Effects of Factor IX Replacement Therapy in Hemophilia BSlide2Slide3
Introduction/OverviewSlide4
Introduction/Overview (cont)Slide5
Importance of Prophylaxis, and Limitations on Its Application, in Hemophilia BSlide6
Key Unmet Need in Hemophilia B:Reducing Patient Burden of DiseaseSlide7
Improving Adherence in Hemophilia BSlide8
Potential Barriers to Adherence in Hemophilia ProphylaxisSlide9
Improving Adherence by Addressing the Barriers to ProphylaxisSlide10Slide11
Surgical Experience With EHL rFIX Replacement TherapySlide12
Annualized Bleeding Rates:Results From the B-LONG StudySlide13
Inhibitor Development in EHL Molecules for Treatment of Hemophilia BSlide14Slide15
Annualized Bleeding Rates:Results From the Nonacog Beta Pegol Phase 3 TrialSlide16
The Importance of Maintaining Trough Levels to Prevent Breakthrough BleedingSlide17
EHL Agents and Treatment IndividualizationSlide18
rFIX-FP Phase 3 Study in Hemophilia B: Study Design Slide19
rFIX-FP Phase 3 Study: AsBRs of Prophylaxis PatientsSlide20
rFIX-FP Phase 3 Study: Safety ResultsSlide21
EHL Agents and Treatment IndividualizationSlide22
Phenotypic Variability Among PWHSlide23
Pharmacokinetic Characteristics of 3 EHL AgentsSlide24
Evolution of FVIII/FIX ConcentratesSlide25
Case Studies With Long-Acting FIX TherapiesSlide26
Introduction/Overview Slide27
Case 1:30-Year-Old Man Typically Treated on DemandSlide28
Case 2:Older Man With a Sedentary LifestyleSlide29
Case 3:Patient Requiring SurgerySlide30
Case 4:Patient With a Frequent Bleeding PhenotypeSlide31
Summary and ConclusionsSlide32
Hemophilia B Treatment GoalsSlide33
The Benefits of EHL Therapies in Hemophilia BSlide34
Transforming the Treatment ParadigmSlide35
AbbreviationsSlide36
Abbreviations (cont)Slide37
Abbreviations (cont)