Our DanaFarber Experience Deirdre Foley amp Matthew Murphy Our DanaFarber Experience Dr O Gorman MIRT Mater Institute of Blood Cancer Research and Therapy and Dr Anderson Dana Farber Cancer Institute Boston ID: 254769
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2012 Student Research
Our Dana-Farber ExperienceDeirdre Foley & Matthew MurphySlide2
Our
Dana-Farber Experience
Dr O Gorman (
MIRT
Mater Institute of Blood Cancer Research and Therapy) and Dr Anderson (Dana Farber Cancer Institute, Boston)
Dr McCann – Student Summer Research Awards
6-weeks student elective at DFCI – mixed clinical and research experience1. Multiple Myeloma out-patient clinics2. Oncology ward rounds at Brigham & Women’s hospital3. Shadowing researchers in Dr Anderson’s lab4. Development of own personal research projectsSlide3Slide4
1. Analysis of Tumour Marker Expression, Karyotype and Cytogenetic Mutations in Patients with Multiple Myeloma at Dana-Farber Cancer Institute
Matthew MurphyOur aim: To analyse the Tumour markers and Cytogenetic profiles of patients with MM at DFCI.
Method: Data on 226 patient cohort with MM at DFCI collected. Analysis of the bone marrow aspirates taken for Flow Cytometry and Fluorescent In-situ Hybridisation (FISH) Cytogenetic Profiling was carried out.
Results: Relative frequency of Tumour markers and Cytogenetic mutations seen in tables.
Now that data has been collected for this specific cohort, collection of the patients’ circulating tumour cells (CTC) and analysis of the genetic mutations present in CTC will allow us to understand the pathology behind what makes MM cells metastasise.
Of particular note a closer analysis of p53 mutation may be interesting to compare as previous data suggest that p53 is key to metastasis.Slide5
Flow Cytometry
& FISH Studies - ResultsSlide6
2. Occurrence of Extra-Medullary Disease in Multiple Myeloma – Analysis of a patient cohort at Dana Farber Cancer Institute
Deirdre Foley
Collection of data from patient files (n=14
)
Focus on-
1. PET-CT reports since diagnosis of Multiple Myeloma – EMD?
2. Plain film radiographs – Lytic bone disease?
3. Laboratory values at diagnosis
Haemoglobin
CreatinineSerum Calcium
Beta-2 microglobulin
. Slide7
Results-
Most common sites of disease were Intra-abdominal and Sub-Cutaneous.
Correlation between bony
plasmacytomas, lytic bone disease, and severity of Extra-medullary disease
View of
plasmacytoma
under microscopy -(http://en.wikipedia.org/wiki/Multiple_myeloma
)
Radiograph of the skull demonstrating a typical lytic lesion in multiple myeloma –(http://emedicine.medscape.com/article/204369-overview )Slide8
Our Dana-Farber Experience
Educational experience - Multiple Myeloma and other haematological malignancies in a both clinical and lab based environmentNovel therapeutic agents – bench to bedside careImportance of international links
Necessity of research in medicineMedicine in an international
setting - differences in practice in US v IrelandSlide9
Time-outSlide10
Thank you to Dr O’Gorman, Dr Anderson and
the Myeloma team at DFCI