A person may experience migraine both with and without aura and the aura experience varies between and within individuals 1 Compared with migraine without aura migraine with aura appears to have ID: 1006901
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1. MigraineMigraine with aura, and migraine without auraA person may experience migraine both with and without aura, and the aura experience varies between and within individuals1Compared with migraine without aura, migraine with aura appears to have:2,3Greater association with certain comorbid conditions Different alterations of brain structure and function as revealed by imaging studiesDifferences in heritability4,5Aura occurs in a minority of people with migraine: ~25%6Most studies of migraine therapies include mixed populations of migraine with and without aura2,3This is problematic, because there is evidence that migraine with and without aura respond differently to treatment2Some have argued that the two conditions – migraine with aura and migraine without aura – should be separated in clinical studies of migraine therapies3ICHD-3=International Classification of Headache Disorders, 3rd edition1. Headache Classification Committee of the International Headache Society (IHS). Cephalalgia 2018;38(1):1–211;2. Hansen & Charles. J Headache Pain 2019;20(1):96; 3. Hauge et al. Cephalalgia 2010;30(9):1041–1048;4. Gervil et al. Ann Neurol 1999;46(4):606–611; 5. Ulrich et al. Ann Neurol 1999;45(2):242–246; 6. Shankar Kikkeri & Nagalli. Migraine with Aura. 2020Migraine with aura is characterised, according to ICHD-3 criteria, by at least 2 migraine attacks with the presence of the following categories of fully reversible aura symptoms:1…and at least 3 of the following 6 characteristics:1At least 1 aura symptom spreads gradually over ≥5 minutes2 or more aura symptoms occur in successionEach individual aura symptom lasts 5–60 minutesAt least 1 aura symptom is unilateralAt least 1 aura symptom is positiveThe aura is accompanied, or followed within 60 minutes, by headacheVisualSensorySpeech and/or languageMotorBrainstemRetinal