Significance and Impact The work provides a promising route for designing a vaccine effective against a broad range of RSV strains which cause serious respiratory disease in infants and older adults ID: 1014134
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1. Scientific AchievementThe molecular structures of human antibodies bound to a respiratory syncytial virus (RSV) surface protein reveal potential targets for antiviral therapies.Significance and ImpactThe work provides a promising route for designing a vaccine effective against a broad range of RSV strains, which cause serious respiratory disease in infants and older adults.Publication about this research: S.O. Fedechkin, N.L. George, J.T. Wolff, L.M. Kauvar, and R.M. DuBois, Sci. Immunol. 3, eaar3534 (2018). Work was performed at Lawrence Berkeley National Laboratory, ALS Beamline 8.3.1. Operation of the ALS is supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences program.Respiratory Virus Study Points to Likely Vaccine TargetStructure of a protective human antibody (gray) bound to a three-dimensional, twisted site on the RSV G protein (cyan).Research DetailsX-ray crystallography showed how protective antibodies bind to a three-dimensional, twisted site on the RSV G protein.The site (the central conserved domain, or CCD) is the same in all strains of RSV.Antibodies that bind the CCD are broadly neutralizing, advantageous for vaccines.