Prepared by Yasser M EL dahdouh Red Blood Cell Indices They are also called red cell absolute values or erythrocyte indices Red blood cell indices are measurements that describe the size and oxygen carrying protein hemoglobin content of red blood cells ID: 469112
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Slide1
Red Blood Cell Indices
Prepared by:
Yasser M. EL-
dahdouh
Slide2
Red Blood Cell Indices
They are also called red cell absolute values or erythrocyte indices.
Red blood cell indices are measurements that describe the size and oxygen- carrying protein( hemoglobin) content of red blood cells.
The indices are used to help in the differential diagnosis of anemia. Slide3
**The relationships between the hematocrit, the hemoglobin, and the red blood cells are converted to red blood cell indices through mathematical formulas.
** The indices include these measurements:
1- Mean corpuscular volume ( MCV).
2- Mean corpuscular hemoglobin ( MCH).
3- Mean corpuscular hemoglobin concentration ( MCHC). Slide4
MCV “ Mean corpuscular volume “
** is the average volume of the RBCs in
femtoliters
( fl ), or 10^-15 L.
MCV = HCT(%) * 10/ RBCs count (10^-12/L )
** Cells of normal size ( MCV is 80 – 100 fl )are called
normocytic
,
Smaller cells are
microcytic
,
Larger cells are
macrocytic
.Slide5
These size catedories are used to classify anemia.
*
Normocytic
anemia have normal size cells and a normal MCV.
*
Microcytic
anemia have small cells and a decreased MCV.
*
Macrocytic
anemia have large cells and a increased MCV.
Example:
Hct
= 45%, RBCs count= 5.0 * 10^12/L,
MCV= 45 * 10 / 5.0 = 90fl.Slide6
MCH “ Mean corpuscular hemoglobin”
** is the average weight of
Hb
in an RBC, expressed in the units of
picograms
( pg) or
( 10^-12g).
MCH=
Hb
(g/dl) * 10 / RBCs count ( 10^12/L).
** Reference range ( 28 – 32 pg ).
** The MCH is not generally considered in the classification of anemia.Slide7
Example:Hb= 16 g/dl.RBCs
connt
= 5.0 * 10^12/L.
MCH= 16.0 * 10 / 5.0= 32.0 pgSlide8
MCHC
** is the average concentration of
Hb
in each individual erythrocyte.
** The units used are gram per deciliter ( formerly referred to as a percentage ).
MCHC=
Hb
(g/dl) * 100 /
Hct
(%)
** Reference range ( 32 – 37 g/dl ).
* Hypo chromic cells are less than 32 g/dl.
* Hyper chromic cells are greater than 37g/dl.
*Values of
normo
chromic cells range from 32 to 37 g/dl. Slide9
Anemia: a variety of condition in which a person blood can not carry as much oxygen as it should due to a decreased number or size of red blood
cells.
Hypochromic
: a descriptive term applied to a red blood cell with a decreased concentration of
Hb
.
Hyperchromic
: a descriptive term applied to a red blood cell with a
increased
concentration of
Hb
.