Hoadley KA et al Cell 1584929944 Background Cancers classified based on pathological criteria tissue site of origin TCGA reported genomewide studies of 10 malignancies Each singletissue cancer type can be divided into 34 molecular subtypes ID: 1040940
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1. Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Hoadley, KA et al. Cell 158(4):929-944
2. BackgroundCancers classified based on pathological criteria – tissue site of originTCGA reported genome-wide studies of 10 malignanciesEach single-tissue cancer type can be divided into 3-4 molecular subtypes
3. MotivationPossible shared molecular alterations across cancers from different tissues - unclearDo disease subtypes span multiple tissues of origin?Molecular signatures may give distinct taxonomy relative to tissue-of-origin-based classification (current method)
4. Pan-Cancer-12
5. COCA“Cluster of cluster assignments”Input : binary vectors representing each platform-specific cluster groupEach platform influences integrated result with weight proportional to # of distinct subtypes from consensus clusteringOutput : Reclusters samples according to vectors
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15. Results1/10 cancer patients classified differently based on new taxonomyGuide new therapeutic decisionsBladder cancers most heterogeneous“Cell-of-origin” features still dominate molecular taxonomy, but refined taxonomy provides independent info