Birth Cohort Studies Health Measures8 July 2021David Bann Associate P - PDF document

Birth Cohort Studies Health Measures8 July 2021David Bann, Associate Professor in Population health, Centre for Longitudinal Studies, UCL Social Research Institute Thanks to our funders and host institution Run major national longitudinal studiesFollow thousands of people across lifeCollect extensive & rich dataProvide free data to research community (see link , UK Data Archive)Documentation, guida

nce & trainingResearchers can input on the data we collect (consultations)Conduct researchMultidisciplinary, substantive & methodological (survey and statistical)What we do at CLS (ESRC funded) 192019401960198020002020 Follow-up across life, N�16,000 cls.ucl.ac.uk 1950196019701980199020002010202020302040YearAgeNext StepsMCSBCS70Mental + physical health outcomesSocial and biological exposures

Note ongoing harmonisation programmes ( CLOSER ): physical activity, diet, cognition, overcrowding, psych Study timelines and future 2020-2030 BirthSchool yearsAdultHousehold compositionParental social class Obstetric historySmoking in pregnancyPregnancy (problems, antenatal care)(length, pain relief, problems)Birthweight, lengthHousehold compositionParental social classParental

employmentFinancial circumstancesHousingHealthCognitive testsEmotionsand behaviourSchoolViews and expectationsAttainmentHousehold compositionEmploymentSocial classIncomeHousingHealth (including biomarkers)Well-beingand mental healthHealth-related behaviourTraining and qualificationsBasic skillsCognitive testsViews and expectationsTypical information covered Time trends in adolescent mental healthSte

phan Collishaw,Barbara Maughan,Robert Goodman,and Andrew Pickles Childhood Risk Factors for Lifetime Anorexia Nervosaby Age 30 Years in a National Birth CohortDASHA E. NICHOLLS, M.B.B.S., M.D., AND RUSSELL M. VINER, M.B.B.S., P.D. Factors associated with childhood cancerin M. Paterson' & L.J. Kinlen2 Breastfeeding and Hospitalization for Diarrheal andRespiratory Infection in the United KingdomMillen

nium Cohort StudyMaria A. Quigley, MSc, Yvonne J. Kelly, PhD, Amanda Sacker, PhD How active are our children? Findings from the Millennium Cohort StudyLucy J Griffiths,1 Mario CortinaBorja,1 Francesco Sera,1 Theodora Pouliou,1 Marco Geraci,1 Carly Rich,1 Tim J Cole,1 Catherine Law,1 Heather Joshi,2 Andrew R Ness,3 Susan A Jebb,4 Carol Dezateux1 201520162017201820192020202120222023 July 2019 In progr

ess Covid - 19 At a glance: core data collections 2015-2020+ Cohort:AgeData availableNCDS 195844/45yYes (UKDS)~62y~2023 (late)BCS 1970Yes (UKDS) Adult biomedical data collections Questionnaire:Household composition, relationships: Finances and employment: Health, wellbeing and cognition: Physical & mental health, mental wellbeing, medical care, medication, smoking, drinking, diet, exercise, cognitiv

e function (as per NCDS Age 50)Word list recall immediate and delayed memory; Animal naming executive function; Letter cancellation concentration / attention to detailNurse measures:Anthropometry, physical function (grip, balance), blood pressure (sitting), blood sample, accelerometry (ActivPalfor 7 days)Online diet questionnaire (Oxford WebQ: 2x24 hour recall) Link to questionnaires Main data avai

lable now ( link ). BCS70 Age 46 Survey Content (N=8,581) Update: Linked health administrative data in the cohorts CountryStudyDataset / information AccessEnglandNCDS, BCS, Next StepsHospital Episodes Statistics (HES) 19972017Admitted Patient Care (APC)Critical Care (CC) linked to APC•Accident & Emergency (A&E)Outpatient Care (OP)Available at UKDS Link via Secure ServerScotlandNCDS, MCSScottis

h Medical Records (SMR)Inpatient OutpatientBirth and Neonatal RecordsPrescribing Information•Maternity•Immunisations(SRS), Child Health Review Available at UKDS via Secure ServerWalesMCSHealth data assets from SAIL Databank (e.g. emergency department, outpatient,COVID data) up to age 14 and for cohort members’ parents•Hospitalisations& no. of diagnoses from ICD 10 chapter codes u

p to age 11Available at Secure Anonymised Information Linkage (SAIL) Databank Available at UKDS via Secure ServerComing soon: HES data from NHS Digital linked to MCSHES refresh: new A&E, APC, CC, OP including COVID19 dataCLS will refresh the Welsh health dataset linked to MCS (20012012) currently available at the UKDS More information available cls.ucl.ac.uk , including HES and SMR user guides and

introductory training webinar video 1958 cohort (NCDS): now available, multiple chips used (single dataset forthcoming)1970 cohort (BCS): expected genotyping in 2021cohort (Next Steps): planning for 2023ohort (MCS): now available, single chip ( Infinium Global Screening Array Trios (cohort, mother, father)New data access system (typically 1 month for a response, simple form) link In future: polyg

enic scores for multiple phenotypesVery exciting future space for research across social & health sci (egs link Update: genetic data possible impacts of pandemic on multiple aspects of life; we need pirical evidence to inform this + longitudinal data likely important five national longitudinal cohort studies were surveyed19y W1 May 2020, W2 Septct 2020 and W3 FebMarch 2021wide range of topics includ

ing family, employment, home schooling, ental health during lockdown and an open question on affects of the pandemic data on UKDS link and overview of content, questionnaires and user guide at CLS link Update: COVID19 data participants who took part in one of three COVIDurveys were invited to provide a fingerprick blood sampletwo antibody tests conducted -N-say and SassayN-say more likely to ident

ify naturally occurring antibodies through exposure to virus S-say more likely to identify antibodies occurring following vaccinationover 10,000 blood samples returnedsame antibody tests conducted in multiple ongitiudinalstudies including ALSPAC, USoc, ELSA, TwinsUK, 1946 cohort funded by National Core StudiesData available end July 2021COVID19 survey serology study Yes!Update: 3 new cohorts?! a two

ESRC funded project starting in April 2021 that will test the feasibility of a new UKwide birth cohort studywill recruit several thousand new babies, collecting nformation about their families and their developmentevaluation early 2023 and if judged to be successful, missioning of a new, larger main study is anticipated in -5extensive UK wide project team and project partnersEarly Life Cohort Feasi

bility Study a new nationally representative birth cohort study of babies in ngland which has been commissioned by the Department for Education (DfE)will answer important scientific and policy questions regarding he family, early education and childcare determinants of early school successwill include babies born April 2021, and seeks to recruit over 8,000 families in early 2022consists of a fiveave

longitudinal survey of children from nine months to five yearsChildren of the 2020s Study a new cohort study of current year 11 (15/16y) students, which ill investigate the educational and employment inequalities brought about by the COVID19 crisisUKRI funded, led by researchers from the UCL Centre for ducation Policy and Equalising Opportunities and the Sutton Trust, in collaboration with CLSlarge

st study of its kind 000 young people to take part will explore disruption to schooling during the pandemic as ell as longerterm educational and career outcomesCOVID Social Mobility and Opportunities (COSMO) study Thank you! Any questions? to help improve the understanding of the risk factors, symptoms treatment of the long term effects of COVIDutilising information collected from more than 60,000 p

eople who e taking part in 11 of the UK’s longitudinal studiesresearch team is based across 13 institutions including CLSpart of Longitudinal Health and Wellbeing National Core Study Research project to investigate long COVID Launched in February 2021Funded by NIHR and UKRI Coverage (questionnaire link Response rate for wave 1 ~37% [tbc]; response weights providedCovid19 data collections, 2020

onwards Initial findingsData expected to be sent to UKDS in summer 2020Covid19 data collections, 2020 onwardsChapters1) Prevalence of COVID 19, symptoms and testing2) Time use and parenting3) Education HE/ FE and apprenticeships (MCS mainly/ only)4) Financial impacts and labour market outcomes5) Changes in selfrated health and health behaviours6) Loneliness, social isolation and mental health7) Acc

ess to care and health services8) Housing, local environment, and access to green space9) In their own words how study members described their experiences and expectations10) Families, social support, and conflict11) Attitudes, compliance and political trust Saliva samples collected from cohort members + resident biological parentsOragene kit assayed using Illumina Infinium Global Screening Array N

saliva samples:Cohort member Main parent Second parent TOTAL Genotyping completed (Bristol); access via special Access Committee (end 2020)Other forthcoming data:MCS7, Age 17 survey ata deposit at UKDS ~ late 2020 MCS update: genetic data (from age 14 saliva samples) 1958 cohort: measures collected at age 61/2y (fieldwork 2019-) within (44/45y) & crosscohort comparability, new research areas:Selfre

port:Health conditions, physical & mental health, mental wellbeing, health behavioursOnline diet questionnaire1/3 life history questionnaire Measured: Cognition (memory, verbal fluency, attention/mental speed)Anthropometrics, body fat %Physical function (grip, balance, walking speed) Blood pressure (resting, standing)Blood (lipids, glucose, stored samples for ‘omics, epigenetics etcCurrently ha

lted due to covid19 pandemic HES -Linkage Number in sweep*Gave consent (% of in sweep)Has matched data(% of consented)Next Steps7,7074,895(63.5)4,579(93.5)BCS709,8417,048(71.6)5,488(77.9)9,7907,065(72.2)6,188(87.6)* Sweep in which consent was sought for linkage:Next Steps: Age 25 SurveyBCS70: Age 42 SurveyNCDS: Age 50 Survey SMR LinkageOnly linked to cohort members who had ever lived in Scotland

45;Ever Scottish’ number in sweep*Gave consent (% of ever-Scottish in sweep)Has matched data(% of consented)MCS1494**(60.7)(99.3)BCS70(Data to be released)(69.7)(78.2)(Data to be released)(63.7)(83.2)* Sweep in which consent was sought for linkage:MCS: Age 7 Survey (consented by their parents)BCS70: Age 42 SurveyNCDS: Age 50 Survey* Linked data excluded if MCS cohort members themselves refused