Van Delden C Iglewski BH CelltoCell Signaling and Pseudomonas aeruginosa Infections Emerg Infect Dis 199844551560 httpsdoiorg103201eid0404980405 ID: 1012380
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1. Figure 3Figure 3. Cell-to-cell signaling systems. Cell-to-cell signaling systems are composed of two genes. The I gene encodes an autoinducer synthase and the R gene encodes a transcriptional activator protein (R-protein). The autoinducer synthase is responsible for the synthesis of an autoinducer molecule (AI), which crosses the cell membrane. With increasing cell-density the intracellular concentration of AI reaches a threshold level, and the AI then binds to the transcriptional activator. The complex R-protein/AI activates the expression of specific target genes.Van Delden C, Iglewski BH. Cell-to-Cell Signaling and Pseudomonas aeruginosa Infections. Emerg Infect Dis. 1998;4(4):551-560. https://doi.org/10.3201/eid0404.980405