Females open circles Males closed squares MalegtFemale MaleltFemale MaleFemale 1 Lecture 31 Example 70 kg and 20 years old 2 Influence of Disease IHepatic and Cardiovascular Diseases ID: 494695
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Slide1
Lecture #31: AD Men vs. Women?
Females = open circles
Males = closed squares
Male>Female
Male<Female
Male=Female
1Slide2
Lecture #31:
Example:
70 kg and 20 years old
2Slide3
Influence of Disease I-Hepatic and Cardiovascular Diseases
Lecture #32
3Slide4
Review: Liver
Lobes of Liver
5-8 – Right Lobe
2-3 – Left Lobe
4 – Quadrate Lobe
1 – Caudate Lobe
4Slide5
Review: Liver Lobule
Central Vein, Hepatic Vein or Hepatic
Venule
Central Vein, Hepatic Vein or Hepatic
Venule
Portal Triad
#1
#2
#3
Liver acinus
Liver
anicus
5Slide6
Review: Liver acinus
Liver
acinus
Central Vein, Hepatic Vein or Hepatic
Venule
Bilecanaliculus
Bile duct
Hepatic artery
branch
Portal vein
branch
Kupffer
cell
Hepatocyte
Septal
Branch
Sinusoid
Stellate
cell
Endothelial cell
with fenestrae
(100 nm in diameter)
Dendritic
cell
Space of
Disse
Hepatocytes
Hepatocytes
Sinusoidal Lumen
Kupffer
cell
Q
Pit cell
Hepatocyte
Bile
canaliculus
Space of
Disse
6Slide7
7Slide8
Liver Fibrosis
8Slide9
Hepatic (Liver) Diseases
Chronic Persistent Hepatitis (book)Chronic hepatitis without piecemeal necrosis (1994)
Chronic Active Hepatitis (book)Chronic hepatitis with piecemeal (periportal) necrosis with or without fibrosis (1994)
Cirrhosis
9Slide10
Liver Diseases: Chronic Persistent Hepatitis
Symptoms
FatigueLack of appetite
Nausea and vomiting
asymptomaticChronic hepatitis without piecemeal necrosis
Causes
Autoimmune diseases (lupus)
Hepatitis B (HBV)Hepatitis C (HCV)Hepatitis D (HDV)
DrugsCryptogenic
10Slide11
Liver Diseases: Chronic Active Hepatitis
Chronic
hepatitisPeriportal
piecemeal necrosis
interface hepatitiswith or without fibrosis
Symptomsmalaise
muscle and joint painfever
nauseavomiting
diarrheaheadache
Causes
Autoimmune diseases (lupus)Hepatitis B (HBV)
Hepatitis C (HCV)
Hepatitis D (HDV)
Drugs
Cryptogenic
p
iecemeal (
periportal
) necrosis
11Slide12
Liver Diseases: Cirrhosis
Causes
12Slide13
13Slide14
b
-lactam antibiotic
penicillins
cephalosporins
14Slide15
o
pioid analgesic
15Slide16
16Slide17
Child-Pugh Score
17Slide18
18Slide19
Red- chronic persistent hepatitis, chronic active hepatitis, cirrhosis
19Slide20
Cardiovascular Diseases
circulatory shock
malignant hypertensionExtremely highDevelops rapidlycongestive heart failure
20Slide21
m
edical diagnostic dye
local anesthetic
Squares – Normal
Closed Circles – mild congestive heart failure
Open Circles – severe congestive heart failure
21
Indocyanine
Green Clearance
(mL/min/kg)Slide22
22
Remifentanil
(
ng
*ml-1)
opioid analgesic