PPT-Regulation of Gene Expression

What does the operon model attempt to explain the coordinated control of gene expression in bacteria bacterial resistance to antibiotics how genes move between homologous regions of DNA the mechanism of viral attachment to a host cell. Eukaryotic Gene Regulation. How are genes turned on & off . in eukaryotes?. How do cells with the same genes differentiate to perform completely different, specialized functions?. Evolution of gene regulation. . Differential . expression, clustering, networks, and functional enrichment. STEMREM 201 Fall 2012. Aaron . Newman, Ph.D.. 10/17/12. A . genomics approach . to . biology involves…. A plethora of . Pre-transcriptional regulation. chromatin compaction . eg. . deacetylation. , . methylation. transcriptional initiation . ie. transcription factors to activate or repress. alternative promoters =. University of Notre Dame. Kristin Hager, Associate Teaching Professor, Biological Sciences. Joseph O’Tousa, Professor, Biological Sciences. WH Freeman. Marc Mazzoni, Senior Editor, Life Sciences. Elaine Palucki, Editor, Adjunct Assistant Professor Biology, Brooklyn College. THINK ABOUT IT . How Does A Cell Know?. Which Gene To . Express. &. Which Gene Should Stay . Silent. ?. Prokaryotic Gene Regulation. @. To conserve resources, prokaryotes regulate their activities, producing only those genes necessary for the cell to function.@ . Chapter . 16. Genes and Development. Proteins can determine the DNA sequence by binding the major groove of DNA.. Proteins binding the minor groove cannot determine the exact sequence of bases.. Prokaryotic gene regulation. How do we regulate the expression of our genes? . Involved in gene expression. DNA regulatory sequences. Regulatory genes. Small regulatory proteins (. RNAs. ). Regulatory sequences. Stretches of DNA that interact with regulatory proteins to control transcription.. The cerebellum is the region of the brain that coordinates motor control, and many human neural disorders impact the cerebellum.. Several spontaneous mouse mutants with motor defects have been found, including:. (Chapter 9). Presented by Dr. Laurie M. Erickson. Chair of the Department of Health Sciences. Blitstein Institute of Hebrew Theological College. Chicago, IL, USA.. Gene Expression can be Regulated.. Gene expression: . Controlling gene expression is often accomplished by controlling transcription initiation.. Regulatory proteins . bind to DNA to either block or stimulate transcription, depending on how they interact with RNA polymerase.. Drosophila. Embryos using . lacZ. Transgenes. June 18. th. ABLE 2014. University of Oregon, Eugene. Cathy Silver Key. Julie Gates. Jessica Sawyer. Kirsten . Guss. Acknowledgements. Funding from . Roberta . Regulating . PROKARYOTIC. Gene Expression. Both prokaryotes and eukaryotes . alter their patterns of gene expression . in . response to changes in environmental conditions. .. During development, gene expression must be carefully regulated to ensure that the right genes are expressed only at the correct time and in the correct place.. We performed a genome-wide analysis of gene expressionto identify germline- and sex-regulated genes.Using mutants that cause defects in germ cell proliferationor gametogenesis, we identiÞed sets of g Pearley Chinta and Juliet V. Spencer . Abstract. Methods. Results. Conclusions. HCMV is a widespread pathogen in the general population and can cause severe disease in immune-compromised hosts. HCMV manipulates immune responses in several ways, one of which includes encoding genes with homology to host chemokine receptors. HCMV US27 encodes a chemokine-like receptor that stimulates host gene expression. While, no chemokine ligand has been identified for US27, it is constitutively active. US27 stimulates the gene expression of antioxidant response element (ARE) regulated genes by activation of the transcription factor nuclear respiratory factor 1 (NRF-1). The goal of this project is to identify specific host and viral genes that are regulated by US27. Increased expression of antioxidant genes is likely to benefit virus infection and enable more progeny virus to be produced. Thus, a better understanding of the US27 function has the potential to lead to the development of novel antiviral therapies necessary to treat HCMV infection. .