Absolute and relative white cells count Absolute value leukocytesmm 3 Total leukocyte count cellsmm 3 X Relative value Example Total leukocyte count 6000 Segmented forms relative no 50 ID: 762576
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Absolute and relative white cells count Absolute value (leukocytes/mm 3 =Total leukocyte count (cells/mm3 X Relative value(%)Example: Total leukocyte count = 6000Segmented forms (relative no.) = 50 %Segmented forms (absolute no.) =6000 X =3000/mm3 50 100
Monocyte Macrophage system Monocytes in blood plus both fixed and wandering macrophages and few specialized endothelial cells in bone marrow, spleen and lymph nodes --------Reticuloendothelial systemBrain: Microglia Skin: Histiocytes Lungs: alveolar macrophages Liver: Kupffer cells Spleen, Bone marrow: Sinusoids Lymphatic Channels: littoral cells
Inflammation 1st line of defense: Macrophages2nd line of defense: Neutrophils 3rd line of defense: Second macrophageinvasion 4th line of defense: increased production ofgranulocytes and monocytes by bonemarrow
Feedback control of the macrophage and Neutrophil responses