CD8 Effector T Cells DIFFERENTIATION OF CD8 T CELLS INTO CYTOTOXIC T LYMPHOCYTES Induction and effector phases of CD8 T cell responses Nature of Antigen and AntigenPresenting Cells for ID: 475815
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Slide1
Differentiation and Functions ofCD8+ Effector T CellsSlide2Slide3
DIFFERENTIATION OF CD8+ T CELLS INTO CYTOTOXIC T LYMPHOCYTESSlide4
Induction and effector phases of CD8+
T cell
responsesSlide5
Nature of Antigen and Antigen-Presenting Cells for Activation of CD8+ T Lymphocytes
The activation of naive CD8+ T cells, like that of all naive
T cells
, is
best
initiated by antigens presented by
dendritic
cellsSlide6
Role of helper T cells in the differentiation of
CD8
+
T lymphocytesSlide7
Role of CytokinesIL-2 promotes
proliferation
and
differentiation
of CD8
+ T cells into CTLs and memory
cells
IL-12
and
type I IFNs
have both been shown to
stimulate the
differentiation
of naive CD8+ T cells into
effector CTLs
IL-15
is important for the
survival of memory
CD8+
and
may be produced by many cell types,
including
dendritic
cells
IL-21
produced by activated CD4+ T cells has
been shown
to play a role in the
induction
of CD8+ T
cell memory
and the
prevention
of CD8+ T cell
exhaustionSlide8
T cell exhaustionSlide9
EFFECTOR FUNCTIONS OF CD8+ CYTOTOXICT LYMPHOCYTESSlide10
Mechanisms of CTL-Mediated CytotoxicitySlide11
Recognition of Antigen and Activation of CTLsSlide12
Mechanisms of CTL-mediated killing of target cellsSlide13
ROLES OF CD8+ CTLs IN HOST DEFENSEIn infections by
intracellular microbes
, the killing
activity of
CTLs is important for eradication of the
reservoir of
infection
Destruction of infected cells by CTLs is a cause of
tissue injury
in some infectious
diseases
CTLs are important mediators of
tumor
immunity
and
the
rejection
of organ transplantsSlide14