Biodegradable lipophilic poly betaamino ester PBAE nanoparticles codeliver mRNA and nucleic acidbased immunomodulatory adjuvant Reprogram the tumor microenvironment in situ to be more immunostimulatory ID: 1032644
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1. Graphical AbstractResearch HighlightsBiodegradable, lipophilic poly (beta-amino ester) (PBAE) nanoparticles co-deliver mRNA and nucleic acid-based immunomodulatory adjuvantReprogram the tumor microenvironment in situ to be more immunostimulatoryInduces tumor-associated antigen-presenting cells to activate cytotoxic lymphocytes against the tumorReprogramming nanoparticle gel synergizes with immune checkpoint blockade to induce tumor regression and clearance