rule in Institute of des Energiestoffwechsels Regel beim - PDF document

rule in Institute of des Energiestoffwechsels Regel beim 542 Sz. results changed I ~ ~ [3 I [ "z~ f ~i \~\~'~-~. MUSCLE o.--o o o I I I i I I I I I I I I I t were measured (DAvIEs 1961). present the between the metabolic Oe ml/dm2/min (0.5 g g 1963) 70 29 25 Average oxygen (striped columns) C - indifferent temperature ° C - NAGY & 544 Sz. and SDA and (Bus~mK et al. 18° C o 6 o ? o-o_ /

o 30 40 50 Fig. 4: Oxygen consumption g hexobarbital weight); temperature colon, interscapular brown under the a thermoneutrat C). colonic- interscat~ular brown muscle temperature are practically into an ambient temperature C, temperatures all three sites fall together about 4 minutes; thereaiter - simultaneously a marked oxygen consumption - brown temperature increases sharply above the oth

er maintains this level throughout cold exposure. (Atier the problem. (CoTTLE & of thermoregutatory van't HoE's in which activity of failed to activity of d ~ O D t ' i i 3 ~u-d I \~ BROWN FAT MUSCLE u. ~-~-z~-~-n-~-n-A ~, u'u. u COLON._. • ,,../ ~ .... 1., ~ ~ ~ % ~ I I I I I I I I I 1 I I I I I I I i I I q I I ! I I I I I Fig. 5: g hexobarbital per kg body weight); temperature colon,

interscapular brown muscle under the brown fat. an ambient temperature C, interscapular brown temperature was considerably higher either colonic temperature. When the had been the cold the thermo- neutral environment C), oxygen consumption decreased immediately, the interscapular brown adipose declined sharply, while deep colonic temperature and temperature underlying the brown showed no ch

ange. Evidently, concurrently the decrease in oxygen consumption in the whole animal, heat production decreased sharply in the brown adipose tissue. heat production. The 546 Sz. o ~ hours after and colonic at an ° C ° C minute periods; the end when the 0 z C i 4 i i ~JA °C 37 35 Fig. 7: Unaesthetized rat, thyroidectom.ized some weeks before, The experiment hours after the electrolytic an

d colonic the metabolic (Fig. 3). the thermogenic of non- (Figs. 4, 5). o ~ t t t * I I I I I ! l ~ I t I 1 Oxygen consumption (lower lines) and rectal temperature lines) of two human premature neonates without signs an adequately warm environment rectal temperature increased C without the metabolic rate. aI. 1962) et al. generally held with body or a~er types of o ~ ~ C ~ °C ~ I ~L~ ~--I

~ ~--L~ 9: Means to hypoxia and body identical in o ~ " t 30 ° C 23 ° C 23 ° C response to a specific oxygen consumption to hypoxia. et al. energy metabolism ¸ - ~ - o ~ i i i 4 and at the metabolic in an C as to an Hg; body ambient temperature. 36 35 15 10 of intact in an saturated with water 6 o unanaesthetized rat, temperature of ° C heat production. 0 2 C ~ an environ- 29.4 o C to

an 35.2 o (b) 37.3 o C (c) 38.6 o C (long, even in demonstrate unequivo- of oxygen o ~ ° C 35 ° C ° C Fig. 16: at an o C (Fig. 9). The high thermoregulatory and severely impaired animal and yet 552 Sz. DO~HOrFrR an ambient temperature of ambient temperature, temperature and 0 2 C bilateral electrolytic lesions in the epithalamus involving the ganglia habenulae. colonic temperature (rig

ht) in a thermoneutraI environment (white columns) at an ambient temperature C (longi- tudinal stripes). in heat production despite marked hyperthermia. (After et al. in which metabolism to the epithalamic 3 ° response to in response to the the a 100 phenomenon and Fig. 18: bilateral lesions in (right) in a (white columns) C (longitudinal stripes) and at (oblique stripes). cold, whereas me

tabolic response hyperthermia had been preserved. al. 1959a) o ~ I J Fig. 19: bilateral epithalamic lesions C (white columns), C (longitudinal stripes) C (oblique stripes). been abolished metabolic response impaired. (Ai%r et al. 1953a) the evidence 554 Sz. fails to (Fig. 13); (Fig. 14) chloralhydrate but - is central nervous increase in response to (Fig. 18); the reverse also holds, hypert

hermia without in response to however, no Table 1 Oxygen consumption and colonic temperature thyroidectomized, hypophysectomized and rats in response hyperthermia; means standard errors. Indifferent temperature: ° C ° C Before thyroxin After thyroxin Before thyroxin + 1 + 1 Body temperature 0.11 38.8 such a rate during activity of temperature might produced through hyperthermia or 29 ° Â

° C errors. (After al. 1959a) consumption ml/dm2/h Colonic temperature o C n = 0.11 39.9 + 0.13 absent n = 37.6 + 0.17 39.9 central regulation hypothalamic and central nervous und mit & T6TEt, & EsTwmi% N. Y. Biol. Bull. Regulation of the whole & TdTH, anism of physiol, hung. E., PAy, physiol, hung. & JARAr, der hyperthermi- & HAuG-LXszL6, physiol, hung. L~isionen des physiol, hung. GY. & j

ARAt, 1959b. 13ber physiol, hung. FIELD, J., BELDING, I-{. S. & cell. cornp. F. A. D. A. metabolic rate in hypo- des Stoffwechsels. isolierte Beeinflussung schenhirn aus. iiber Gewebsatmung. 165, 102-117. Body size Proc. Soc. A., t950. Body size tissue respiration. Biochirn. biophys. rdber die Pfliigers Arch. ges. Physiol. als wesentlicher 1958. fdber das SZ., 1959a. SZ., 1959b. I3ber das K

/Srpertemperatur der E. & HeIM, (Oxygen consumption of the J. M., acid monolayers. Discuss. Faraday Soc. 6, 160-165. R. E., 1962. by brown adipose tissue adipose tissue. R. J., 1963. thermogenic effector 140, 199-200. J. C., adipose tissue cold-acclimated rats. J. Physiol. E. F. & Roc~t~, J., in vitro tissus homologues. 24, 356-399. F. W. & Proc. Soc. 49, 367-370. L~iflt si& aus der O2-Aufna

hme, der Hypothatamusl~isionen die RGT-Regel zu erwartende Muskelaktivit~it oder - wie Frage ist voraussetzen. Setzt Tiere der die gezeigten Resultate. Wilrme aus, so finder ist nicht einfach. Zwei 558 Sz. effekte sind unterscheiden, die bei G~,E~, J. Endocrinol. Metab. wie die Adrenocortex-PankreasinseI-Apparates, die gezielten Eingriff Nachweis liet~e sich histologisch untersucht oder) di

e Auflerdem sollte exakt er- Me&anismen. Die Veritnderungen die vers&iedenartigsten Folgen, die anatomisch auch nicht scharf lokalisieren oder blieb er gemessen, nachdem hatte. Viele eine glei&zeitige St6rung der chemischen der K/Srpertempe- ffir jede eine gegen- regulatorische Steigerung. entsteht der als ob Wirkli&keit handelt Auch bei Sauerstoffverbrauches gesehen. to our experiments a ex

ists between The rats acclimated to 0 ° C respectively the greatest Animals adapted to + after cold exposition. colonic temperature? was the &ange presented pictures measured? animals were room temperature. the experiments was measured experiments we measured became adapted. Versu&e lassen si& pherer Thermogenese gibt, ohne kommt. Erg~inzend (Wien) hinweisen, Frequenz bei der Tiere Eine Erk

l~irung gesteuerte Verlagerung peripherer Thermogenese bei ersterer. Sicher spielt bei Thermogenese die elektris&e Aktivit~it Muskeln eine Rolle. Auskiinite fiber das s&nelle mittelschnelle (Std., Tage) System der Stoffwe&sel- automatischen Dauerregistrie- rungen zu Ergebnissen fiihren, ist die Messung bequemer Methode gearbeitet, die sehr s&nelle, zugleich auch Iangfristige Messungen gestat