The connection between chocolate and migraine has long been contested 1 Across a range of epidemiological studies including thousands of people with migraine up to 225 of people report ID: 1030505
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1. MigraineIs chocolate a trigger or not?The connection between chocolate and migraine has long been contested1Across a range of epidemiological studies, including thousands of people with migraine, up to 22.5% of people report chocolate as a headache trigger1The tyramine in chocolate has been investigated in migraine, however, a link has not been established1The phenylethylamine contained in chocolate has been shown experimentally to cause headaches1In one seminal study, 25 people with migraine were given either 44 g of chocolate or a matched placebo;a participants were told these were two different sorts of chocolate2Participants were asked to respond 48 hours after the experiment indicating whether or not they had experienced a migraine2In total, 9 headaches occurred after chocolate ingestion, whilst 6 occurred after placebo, without a significant difference between the two groups (p=0.54)1,2Other provocative studies have failed to show a significant difference in headache attacks between chocolate and placebo1aConsisting of a synthetic fat which approximated in physical quality to cocoa butter, but which was made from non-cocoa containing vegetable oils1. Lippi et al. Acta Biomed 2014;85(3):216–221; 2. Moffett et al. J Neurol Neurosurg Psychiatry 1974;37(4):445–448Many people report chocolate as a migraine trigger, but the basis for chocolate precipitating migraine attacks is largely anecdotal1