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Anti-Inflammatory and Anti-Cancer effects of thioalkaloids Anti-Inflammatory and Anti-Cancer effects of thioalkaloids

Anti-Inflammatory and Anti-Cancer effects of thioalkaloids - PowerPoint Presentation

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Anti-Inflammatory and Anti-Cancer effects of thioalkaloids - PPT Presentation

Nuphar lutea yellow Water Lilly MCF7 Breast cancer cell line Ozer J et alCancer Biol Ther 2009 Oct81918608 Vehicle NUP Cisplatin NUPCisplatin 6hydroxythiobinupharidine 6hydroxythionuphlutine B ID: 317410

infected cells measles cancer cells infected cancer measles cell ukf line protein mirna nup virus cisplatin regulated anti host

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Slide1

Anti-Inflammatory and Anti-Cancer effects of thioalkaloids from Nuphar lutea (yellow Water Lilly).Slide2

MCF-7 Breast cancer cell line

Ozer J et al.Cancer Biol Ther. 2009 Oct;8(19):1860-8 Slide3

Vehicle

NUP

Cisplatin

NUP+CisplatinSlide4

6-hydroxythiobinupharidine

6-hydroxythionuphlutine B

Slide5

The role of host-encoded microRNAs in maintaining measles virus persistence

Jacob Gopas Ph.D.

Department

of Microbiology and Immunology, Faculty of Health Sciences.

Ben

Gurion

University and

Laboratory

of Oncology

Soroka

Medical Center

Beer

Sheva

,

Israel

Glenn Rall Ph.D.

Program

in Immune Cell Development and Host Defense, Fox Chase Cancer Center, Philadelphia, USA.Slide6

Expression of Measles Virus P-protein

Measles P-protein

KMH2

KMH2MV

L428

L428MV

UKF

UKFMV

VERO

VEROMV

NS20

2716MV

Western blot

Vero-SLAM- GFP-P proteinSlide7
Slide8
Slide9
Slide10

Alterations in miRNA levels in cells infected with measles . The results demonstrate the difference between uninfected cells to infected cells. Each cell line was tested at least

by triplicate. Each

miRNA

was

examined in three different libraries

of each cell line. Has-222-3p is down-regulated in infected KMH-2 and UKF cells. Has-124-3p is up-regulated in infected UKF cells.