Matching 20152016 Abdelghani Abid BinTarif Bob J Statham Anna B Ludi Donald P King FMD Reference Laboratory The Pirbright Institute is the OIE FAO and EU Reference Laboratory for footandmouth disease FMD The Serum Assay Unit carries out vaccine mat ID: 731084
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Slide1
The challenges of using in-vitro tests for Vaccine Matching (2015-2016)
Abdelghani (Abid) Bin-Tarif | Bob J. Statham | Anna B. Ludi | Donald P. King
FMD Reference LaboratorySlide2
The Pirbright
Institute is the OIE, FAO and EU Reference Laboratory for foot-and-mouth disease (FMD). The Serum Assay Unit carries out vaccine matching tests for international samples received by the World Reference Laboratory (WRL), to characterise the antigenic relationship (r1-value) between circulating field strains and vaccine.IntroductionSamples processing stepsSlide3
More than 195 samples submitted to WRL-FMD between submitted between Jan.2015-Oct 2016 from 27 different countries.
Samples submitted to WRL-FMD2015-2016Slide4
Serotype A:
33 field isolates have been tested by VNT from five different pools, results show good match with the vaccine strains in pools 1 and 5, but show poor match in pools 3, 4 and 6.The new lineage G-VII in pool 1 has a poor match against all vaccine viruses available in the SAU.Serotype O: 60 field isolates have been tested by VNT from five different pools. Results show good match with the vaccine strains in all pools.
Results Slide5
Future
In the future the WRL along with international reference laboratories of the OIE/FAO Network is working to harmonise and improve the robustness and repeatability of the vaccine-matching test.Acknowledgements
Don King, Anna Ludi,
Bob Statham, Ginette
Wilsden and Clare Browning
Central Service Unit (CSU)World Reference Lab (WRL)
You for submitting samples
Vaccine companies for supplying reagents
and
EuFMD
for allowing me to present
Many Thanks
.