Scott Needham September 2013 Who amp Why Leading Technology Group has been investing in life sciences field Our future investment focus is on SENS type opportunities in particular vascular ID: 257075
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Slide1
Towards Priorities for Aging Research
Scott NeedhamSeptember, 2013Slide2
Who & Why?
Leading Technology Group has been investing in life sciences fieldOur
future investment
focus is on SENS
type opportunities, in particular vascular agingHere we discuss the prioritisation approach that lead to this decisionSlide3
Aim: Priorities for Aging Research
Ideally, with a SENS view, we would prioritise instances of aging damageNo standard definitions or demographic data on damage, so we prioritise disease
We use Australian Burden of Disease Data
Here we briefly review the path to our approach and the resultsSlide4
Character of MortalitySlide5
Disease Curves Vary
(Simms 1946)
(
Kohn 1963
)Slide6
Disease Curves Vary Over Lifespan
(
Horiuchi, Finch et. al. 2003
)Slide7
High-level Findings
Accelerate in old age/post reproductive:
Dementia (
Vascular & Alzheimer’s)
Several infectious diseases (Influenza)
Accidental injuries associated with
frail musculoskeletal system
(
F
alls
,
Suffocation
etc
)
Digestive system (Bowel
obstruction
)
Genital/urinary system (
K
idney disease)
Decelerate in old age/post reproductive
Life style:
heavy drinking
(Liver disease),
smoking
(Lung cancer),
and obesity
(Type 2 Diabetes)
Disease
history
(Rheumatic
heart
disease, Hepatitis)
G
enetic
factors
(Multiple
sclerosis, some
Cancer)Slide8
Summary Interpretation
Accelerating:
dominated by senescent
processes from normal metabolism
Decelerating: dominated by individual specific risk factors
With a focus on aging, our ranking should
Over weight diseases that accelerate
Under weight diseases that decelerate Slide9
Prioritisation
Several methods were considered:
Rank
by
old age mortality growth rate and accelerationExclude risk factor associated deaths Two simple ranking methods chosen. Diseases are ranked by their relative:
% of Deaths for Ages 60+, post reproductive
% of Deaths for Ages 85+, oldest old
DALYs too, largely alignedSlide10
Increasing Ranking
Genital/
Urinary
Acute
Respiratory
Dementia
Digestive
FallsSlide11
Steady-Decreasing Ranking
COPD
Type 2 Diabetes
Lung Cancer
SuicideSlide12
CancerSlide13
Cancer
Prostate
Colorectal
Breast
BrainSlide14
Cardiovascular
All Other
Cardiovascular
CancerSlide15
Vascular Aging
All Other
Cardiovascular
Cancer
Ischaemic
Heart Disease and StrokeSlide16
Current Research Funding
(
Gillum
,
Gouveia
et al. 2011)
Mortality (All Ages)
Funding (NIH)
Ischaemic
Heart Disease and Stroke
33%
6
%