Creating CoQ10 Products Manufacturing CoQ10 supplements, foods and creams requires attention - PowerPoint Presentation

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Creating CoQ10 Products

Manufacturing CoQ10 supplements, foods and creams requires attention to health effects, different forms, bioavailability issues and delivery formats.

CoQ10 101

CoQ10 is an essential nutrient used in the production of mitochondrial energy.

Ubiquinone

is the fully oxidized form (CoQ10) and

ubiquinol

is the reduced form (CoQ10H2).

Ubiquinone

is used in the synthesis of adenosine

triphosphate

(ATP), the body’s form of chemical energy.

Ubiquinol

is an antioxidant that protects against oxidation and helps to produce other antioxidants.

Ubiquinol

and

ubiquinone

form a

redox

(reduction-oxidation) pair and can be converted from one form to the other in cells.

As the body ages, it naturally produces less CoQ10. Chronic diseases, such as heart disease and diabetes, are also accompanied by a decline in CoQ10 levels.

Coco for CoQ10

Consumers rated CoQ10 as their fifth most popular supplement in a November 2011consumerlab.com survey. The results of the 10,000-respondent survey showed about half of those polled took CoQ10. Consumerlab.com noted it was also the fifth top-selling supplement in 2010, with 53 percent of supplement users adding it to their daily routine.

The consumerlab.com survey found men favored supplements such as CoQ10 that promise to boost energy, slow aging and lower cholesterol, and older supplement users were more likely to take CoQ10 than younger users. CoQ10 was also preferred by those who take multiple supplements.

CoQ10 for the Heart

In an Israeli, double blind, placebo-controlled, randomized study, 60 mg/d of CoQ10 (as

Ultrasome

™ from

Herbamed

) led to an improvement in functional status, clinical symptoms and quality of life in

heart transplant candidates

after three months.

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German researchers found

Kaneka’s

ubiquinol

reduced low-density lipoprotein (LDL) cholesterol in men after two weeks.

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Supplementing with CoQ10 has also been shown to reduce hypertension

3

and coronary atherosclerosis.

4

CoQ10 caused sustained clinical improvement in heart muscle contraction, and reduced fatigue, chest pain, shortness of breath, exercise ability and palpitations.

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CoQ10 supplementation can also protect against ischemia and reperfusion injury.

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CoQ10 for the Brain & Sports

A Cornell University, New York, study found

neuroprotection

against

a model of Parkinson's

disease using both

ubiquinone

(from

Tishcon

) and

ubiquinol

(from Kaneka).

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The researchers found

ubiquinol

produced larger increases in plasma concentrations of CoQ10.

The nutrient further helps the head by reducing

migraine frequency and disability,

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as well as tinnitus (ringing in the ears).

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CoQ10

improved swimming endurance and had an anti-fatigue effect in mice in a 2010 study.

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And

a 2010 review reported studies have confirmed CoQ10’s effect in reducing fatigue and exercise-related damage, and improving physical

performance.

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Different Forms of CoQ10

Because the body converts

ubiquinone

(CoQ10) into

ubiquinol

, some feel it is better to supplement with

ubiquinol

, reducing the body's need to transform it. Some people cannot convert CoQ10 to

ubiquinol

efficiently due to compromised activity of the enzyme

(CoQ10

reductase

) in charge of facilitating the transition.

Because it has two extra electrons,

ubiquinol

can act as an antioxidant, whereas CoQ10 does not, so some argue that

ubiquinol

is a better supplement.

However, others say

ubiquinone

is more stable, and easier to formulate and store.

Absorption Issues

An

April 2001

review noted supplementation

with CoQ10 has potential therapeutic value in several health areas, but clinical efficacy is limited due to challenges with bioavailability and absorption.

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However, new

formulations

may improve bioavailability.

CoQ10

is poorly absorbed because its crystals are too large for cells to

absorb, and it

is fat

soluble,

making it difficult to transport through the digestive system.

Increasing Absorption

Ingredient suppliers offer technology to boost CoQ10 absorption:

Maypro, in partnership with

Bioactives

LLC, markets

MicroActive

® CoQ10, a water-dispersible form of CoQ10.

Maypro also offers BioQ10 SA™, CoQ10 combined with soy protein.

Triarco’s

Aqua 10® is a patented, water-dispersible CoQ10 powder .

Herbamed's

Ultrasome

™ is CoQ10 packaged into a

nano

-droplet,

solubilized

in oil, then surrounded by a phospholipid shell.

Soft Gel Technologies'

CoQsol

-CF™ formula combines CoQ10 with mixed carotenoids and mixed

tocopherols

, in a base of rice bran oil.

Delivery

CoQ10 comes in a variety of delivery forms, such as capsules, tablets,

softgels

, droppers, beverages and skin creams.

Supplements are the most popular format, but new technologies have allowed it to be incorporated into functional foods and beverages.

Skin care creams with CoQ10 are also increasing in popularity.

Manufacturing

CoQ10 can be difficult to work with because it's fat soluble and has poor bioavailability. It has to be handled carefully and protected from heat and light.

Ubiquinol

is unstable and on exposure to air, can convert to

ubiquinone

.

Oil carriers and

softgels

can help boost bioavailability, but they limit manufacturer options.

Third-party seals, such as the USP Ingredient Verification program, can help ensure CoQ10 quality.